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Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes

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Mechanisms of Lymphocyte Activation and Immune Regulation VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 406))

Abstract

The regulated initiation of programs leading to cell death is responsible, at least in part, for maintaining homeostasis within the immune system. Two general mechanisms for the production of cytotoxicity in susceptible targets by T effector cells have been described, one involving Ca++ dependent, perforin/granzyme exocytosis, and the other involving Fas antigen (CD95) engagement1. Fas functions in target cells as a receptor that signals for apoptosis, and Fas has been implicated in the process of reducing lymphocyte numbers following acute immune responses, termed activation induced cell death2–8. Although classical CD8+ cytotoxic T lymphocytes have recently been shown to express both types of cytotoxic activity, a distinct class of T cells, with the phenotype of CD4+ Th1 cells, mediates target cell death primarily in a Fas-dependent fashion9–14.

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Authors and Affiliations

  1. The Department of Medicine and The Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, Massachusetts, 02118, USA

    Dr. Thomas L. Rothstein & Shry-Te Ju

  2. The Department of Microbiology, Boston University Medical Center, Boston, Massachusetts, 02118, USA

    Dr. Thomas L. Rothstein, Linda C. Foote, Thomas J. Schneider, Gavin M. Fischer, Bruce A. Jacobson & Ann Marshak-Rothstein

  3. Department of Immunobiology, Immunex Research and Development Corporation, Seattle, Washington, 98101, USA

    David H. Lynch

  4. The Department of Pathology, Boston University Medical Center, Boston, Massachusetts, 02118, USA

    Shry-Te Ju & Ann Marshak-Rothstein

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  1. Dr. Thomas L. Rothstein
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  2. Linda C. Foote
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Correspondence to Thomas L. Rothstein .

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  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    J. John Cohen

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Rothstein, T.L. et al. (1996). Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_19

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