Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes

  • John Gordon
  • Christopher D. Gregory
  • Gillian Grafton
  • John D. Pound
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)


B lymphocytes are subject to selection within germinal centers following somatic hyper-mutation on immunoglobulin variable region genes based on their ability to bind antigen with high affinity. Non-selected cells die by apoptosis. Tumors with features of germinal center B cells include follicular center cell lymphoma and Burkitt’s lymphoma. We have used the latter extensively as a neoplastic model of germinal center cells and have compared directly the behaviour of cell lines dervied from biopsy material with that of the normal counterparts. Here we describe some of our findings in the two systems with regard to signals regulating survival and apoptosis.


Germinal Center Burkitt Lymphoma Cell Germinal Center BCELLS Germinal Center Cell Burkitt Lymphoma Cell Line 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • John Gordon
    • 2
  • Christopher D. Gregory
    • 1
  • Gillian Grafton
    • 1
  • John D. Pound
    • 1
  1. 1.Department of ImmunologyThe Medical SchoolBirminghamUK
  2. 2.Department of ImmunologyThe Medical SchoolBirminghamUK

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