Fas Splicing Variants and their Effect on Apoptosis

  • Giovina Ruberti
  • Isabella Cascino
  • Giuliana Papoff
  • Adriana Eramo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)


Higher vertebrates frequently contain multigene families of related ligands and their receptors, often with overlapping specificities. Presumably such an organization allows for greater flexibility in the timing and tissue distribution of these molecules. A further level of complexity is introduced by the fact that variants of the same growth factor or receptor can be encoded as alternative transcripts of the same gene. Such variants may remain membrane associated or may be efficiently secreted.


Death Domain Acidic Sphingomyelinase Resistant Cell Clone HUT78 Cell Line Peripheral Blood Mononuclear Cell Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Giovina Ruberti
    • 1
  • Isabella Cascino
    • 1
  • Giuliana Papoff
    • 1
  • Adriana Eramo
    • 1
  1. 1.Department of Immunobiology Institute of Cell BiologyNational Research CouncilRomeItaly

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