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Fas Splicing Variants and their Effect on Apoptosis

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Mechanisms of Lymphocyte Activation and Immune Regulation VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 406))

Abstract

Higher vertebrates frequently contain multigene families of related ligands and their receptors, often with overlapping specificities. Presumably such an organization allows for greater flexibility in the timing and tissue distribution of these molecules. A further level of complexity is introduced by the fact that variants of the same growth factor or receptor can be encoded as alternative transcripts of the same gene. Such variants may remain membrane associated or may be efficiently secreted.

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Authors and Affiliations

  1. Department of Immunobiology Institute of Cell Biology, National Research Council, Rome, Italy

    Giovina Ruberti, Isabella Cascino, Giuliana Papoff & Adriana Eramo

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  1. Giovina Ruberti
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  2. Isabella Cascino
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  3. Giuliana Papoff
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  4. Adriana Eramo
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Correspondence to Giovina Ruberti .

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  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    J. John Cohen

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Ruberti, G., Cascino, I., Papoff, G., Eramo, A. (1996). Fas Splicing Variants and their Effect on Apoptosis. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_13

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