Sleep Facilitating Effects of Vitamin B12

  • Hiroshi Itoh
  • Motohiro Ozone
  • Mitsuo Sasaki


Recent experiments (Kamgar-Paris 1983, Okawa 1990) have shown that vitamin B12 (Vit. B12) has therapeutic effects on circadian rhythm sleep disorders, such as delayed sleep phase syndrome (DSPS) and non-24 hours sleep wake rhythm disorder (Non-24). Regarding the mechanisms of therapeutic action of Vit. B12 on circadian rhythms sleep wake disorders, many study consider its effects on the phase or period of circadian rhythms and on photo sensitivity. But at the present time the definite mechanisms of action are still unclear.


Sleep Onset Sleep Latency Slow Wave Sleep Sleep Parameter Delay Sleep Phase Syndrome 
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  1. Bereger, R.J., Palca, J.W. and Walker, J.M., 1988, Correlations between body temperature, metabolicrate and slow wave sleep, Neurosci. Lett. 86: 230–234.CrossRefGoogle Scholar
  2. Honma, K., Honma, S., Kohsaka, M., Morita, N. and Fukuda, N., 1991, Does metylcobalamin (vitamin B12) increase the light sensitivity of human circadian clock?, Jpn. J. Psychiat. Neurol. 45 (1): 171–172.Google Scholar
  3. Home, J.A. and Schackell, B.S., 1987, Slow wave sleep elevation after body heating: Proximity to sleep and effects of aspirin, Sleep. 10 (4): 383–392.Google Scholar
  4. Inoue, S., Honda, K., Uchizono, K., Ueno, R. and Hayaishi, O., 1984, Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats, Proc. Natl. Acad. Sci. USA. 81: 6240–6244.PubMedCrossRefGoogle Scholar
  5. Inoue, S. and Honda, K., 1991, Sleep-promoting and temperature modulatory activities of vitamin B12 in rats, Jpn. J. Psychiatry. Neurol. 45: 943–944.Google Scholar
  6. Inoue, S., 1993, Sleep-promoting effects of vitamin B12, in: Sleep—wake rhythm disorders, (K. Takahasi, ed.), pp. 1–6, Intermed, Tokyo, (in Japanese).Google Scholar
  7. Kamgar-Parsi, B., Wehr, T.A. and Gillin, J.C., 1983, Successful treatment of human non-24-hour sleep—wake cycle syndrome, Sleep. 6: 257–262.PubMedGoogle Scholar
  8. Ohta, T., Ando, K., Iwata, T., Ozaki, N., Kayukawa, Y, Terashima, M., Okada, T. and Kasahara, Y, 1991, Treatment of persistent sleep—wake schedule disorders in adolescent with methylcobalamin (vitamin B12), Sleep. 14(5): 414–418.PubMedGoogle Scholar
  9. Okawa, M., Mishima, K., Nanami, T., Shimizu, T., Iijima, S., Hishikawa, Y and Takahashi, K., 1990, Vitamin B12 treatment for sleep—wake rhythm disorders, Sleep. 13(1): 15–23.PubMedGoogle Scholar
  10. Sakamoto, T., Nakazawa, Y, Utiyama, N. and Tutiyama, Y, 1993, Sleep and temperature rhythm in the elderly, Clinical Psychiatry. 35(2): 145–152. (in Japanese).Google Scholar
  11. Takahashi, K., Morita, N., Mishima, K., Kanako, M, Higuti, T., Sakamoto, K., Sasaki, M, Okawa, T., Yamadera, H., Okamoto, N., Ohta, T., Sugita, Y, Tamiya, M., Kotorii, T. and Takahashi, S., 1994, A multicenter study on sleep—wake rhythm disorders in Japan, Clinical Psychiatry. 36(3): 275–284. (in Japanese).Google Scholar
  12. Tsujimaru, S., Ida, Y, Satoh, H., Egami, H., Shirao, I., Mukasa, H. and Nakazawa, Y, 1992, Vitamin B12 accelerates re-entrainment of activity rhythms in rats, Life Science. 50: 1843–1850.CrossRefGoogle Scholar
  13. Uchiyama, M., Mayer, G., Okawa, M. and Meier-Ewert, K., 1995, Effects of vitamin B12 on human circadian body temperature rhythm, Neurosci. Lett. 192: 1–4.PubMedCrossRefGoogle Scholar
  14. Yamazaki, J., Sugishita, M., Moriya, Y, Isojima, G., Ohshima, H., Yamazaki, O., Takeda, Y, Yamauchi, T., Takeshima, M. and Takahashi, Y, 1991, The effects of vitamin B12 on the suppression of melatonin secretion under illumination, Jpn. J. Psychiat. Neurol. 45(1): 169–170.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Hiroshi Itoh
    • 1
  • Motohiro Ozone
    • 1
  • Mitsuo Sasaki
    • 1
  1. 1.Department of PsychiatryThe JIKEI University School of MedicineTokyo 105Japan

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