Abstract
The hypothesis that the sleep/wake changes inherent in the narcolepsy—cataplexy syndrome might be caused by a biological rhythm disturbance was introduced at the First International Conference on Narcolepsy in Montpellier (Kripke, 1976). This proposition was in part based on the prior observations that diurnal sleep is increased and nocturnal sleep decreased in narcolepsy and that, after abrupt phase shifting of the sleep/wake schedule, normal subjects experience fatigue during the new “subjective day,” at times experience insomnia and, like patients with narcolepsy, can show REM onset sleep during the new subjective night (Weitzman, Kripke, Goldmacher, McGregor, and Nogeire, 1970; Kripke, Lewis, and Cook, 1971). Kripke’s thesis was that circadian rhythm desynchronization may underlie both the nocturnal sleep disruption and daytime wake maintenance problems in narcolepsy, and that the pattern of multiple sleep episodes during the day might be due to intrusion of intensified ultradian oscillators into a weak and insufficient circadian synchronizing system. Kripke’s seminal article also contains the insightful statement antedating later postulates of problems of state boundary control when he wrote (Kripke, 1976, p. 479):
“Narcolepsy is a great teacher that we should not regard sleep or the sleep stages as unitary states, but rather as various components which may become qualitatively or quantitatively dissociated.”
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References
Ahmed S, Sack RL, Rich GB, Lewy AJ. Twenty-four hour secretion of melatonin is normal in narcoleptics. Sleep Research 1991; 20: 194.
Aschoff J. Zeitliche Strukturen biologischer Vorgänge. Acta Leopoldina 1959;21: 147–77.
Aschoff J. Circadian rhythms in man. Science 1965;148: 1427–32.
Aschoff J. Circadian rhythms: Interference with and dependence on work-rest schedules. In: Johnson LC, Tepas DI, Colquhoun WP, Colligan MJ, eds. The 24 hour Workday: Proceedings of a symposium on variations in work-sleep schedules. Washington DC: National Institute for Occupational Safety and Health, 1980.
Aschoff J. A survey on biological rhythms. In: Aschoff J, ed. Handbook of Behavioral Neurobiology. Volume 4, Biological Rhythms. New York: Plenum Press, 1981: 3–10.
Aschoff J, Gerecke U, Wever R. Desynchronization of human circadian rhythms. Japanese Journal of Physiology 1967;17:450–57.
Baldy-Moulinier M, Arguner A, Besset A. Ultradian and circadian rhythms in sleep and wakefulness. In: Guilleminault C, Dement WC, Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976; 485–98.
Besset A, Billiard M, Crastes de Paulet A, Passouant P. Secretion de GH et de cortisol en rapport avec les etats de vigilance au cours du nycthemere chez 10 narcoleptiques. Rev EEG Neurophysiol 1976;6: 17–22.
Billiard M, Besset A, Cadilhac J. The clinical and polygraphic development of narcolepsy. In: Guilleminault C, Lugaresi E, eds. Sleep/wake disorders: Natural history, epidemiology and long-term evolution. New York: Raven Press, 1983: 171–85.
Billiard M, Quera Salva M, DeKoninck J, Besset A, Touchon J, Cadilhac J. Daytime sleep characteristics and their relationships with night sleep in the narcoleptic patient. Sleep 1986;9: 167–74.
Borbely AA. A two-process model of sleep regulation. Human Neurobiology 1982;1: 195–204.
Borbely AA, Ackermann P, Trachsel L, Tobler I. Sleep initiation and sleep intensity: Interactions of homeostatic and circadian mechanisms. J Biol Rhythms 1989;4: 149–60.
Bourgine N, Claustrat B, Besset A, Billiard M. Circadian patterns of melatonin secretion in narcoleptic patients and in controls. In: Koella WP, Obál F, Schulz H, Visser P, eds. Sleep ‘86. Stuttgart: Gustav Fischer Verlag, 1988: 420–1.
Broughton RJ. Biorhythmic variations in consciousness and psychological functions. Can Psychol Rev 1975;16: 217–30.
Broughton RJ. Discussion. In: Guilleminault C, Dement WC, Passouant P, eds. Narcolepsy. New York: Spectrum, 1976: 667.
Broughton RJ. Performance and evoked potential measures of various forms of daytime sleepiness. Sleep 1982;5: S135–46.
Broughton RJ. Three central issues concerning ultradian rhythms. In: Schulz H, Lavie P, eds. Ultradian rhythms in physiology and behavior. Berlin: Springer-Verlag, 1985: 217–33.
Broughton RJ. Zur Lokalisation der Schlaf-Wach-Regulierung. In: Meier-Ewert K, Schulz H, eds. Schlaf und Schlafstörungen. Heidelberg: Springer Verlag, 1990: 120–31.
Broughton RJ. Important underemphasized aspects of sleep onset. In: Ogilvie R, Harsh J, eds. Sleep onset: Normal and abnormal processes. Washington DC: American Psychological Association, 1994: 19–36.
Broughton RJ, Aguirre M. Evidence for qualitatively different types of excessive daytime sleepiness. In: Koella WP, Ruther E, Schulz H, eds. Sleep ‘84. Stuttgart: Fisher-Verlag, 1985: 86–7.
Broughton RJ, Aguirre M. Differences between REM and NREM sleepiness measured by event-related potentials (P300, CNV), MSLT and subjective estimate in narcolepsy—cataplexy. Electroencephalogr Clin Neurophysiol 1987; 67: 317–326.
Broughton RJ, Mamelak M. Effects of gamma-hydroxy-butyrate on sleep/wake patterns in narcolepsy—cataplexy. Can J Neurol Sci 1980;7:23–31.
Broughton RJ, Valley V, Aguirre M, Roberts J, Suwalski W, Dunham W. Excessive daytime sleepiness and the pathophysiology of narcolepsy—cataplexy: a laboratory perspective. Sleep 1986;9: 205–15.
Broughton RJ, Dunham W, Newman J, Lutley K, Duschesne P, Rivers M. Ambulatory 24 hour sleep—wake monitoring in narcolepsy—cataplexy compared to matched controls. Electroencephalogr Clin Neurophysiol 1988;70: 473–81.
Broughton RJ, Campbell S, Dunham W. Curve fitting of chronobiological data: some issues and techniques. Sleep Research 1993;22: 395.
Broughton RJ, Dunham W, Weisskopf M, Rivers M. Night sleep does not predict day sleep in narcolepsy. Electroencephalogr Clin Neurophysiol 1994;91: 67–70.
Broughton RJ, Dunham W, Krupa S, Mullington J. Timing of midday naps is closely coupled with morning wake-up time. Sleep Research 1995a;24: 513.
Broughton RJ, Dunham W, Krupa S, Mullington J. Impairment of waking arousal in narcolepsy. Sleep Research 1995b; 24:206.
Campbell SS, Broughton RJ. Rapid decline in body temperature before sleep: fluffing the physiological pillow? Chronobiology International 1994; 11: 126–31.
Campbell SS, Zulley J. Ultradian components of sleep/wake patterns during disentrainment. In: Schulz H, Lavie P, eds. Ultradian Rhythms in Physiology & Behaviour. Heidelberg: Springer Verlag, 1985: 234–55.
Carskadon, MA. The role of sleep-onset REM periods in narcolepsy. In: Guillemineault C, Dement WC, Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976: 499–519.
Carskadon MA, Dement WC. Sleep studies on a 90-minute day. Electroencephalogr Clin Neurophysiol 1975;39: 145–55.
Carskadon MA, Dement WC. Sleepiness and sleep state on a 90-minute schedule. Psychophysiology 1977; 14: 127–33.
Carskadon MA, Dement WC. Effects of total sleep loss on sleep tendency. Perceptual and Motor Skills, 1979;48: 495–506.
Czeisler CA, Zimmerman JC, Ronda JM, Moore-Ede MC, Weitzman ED. Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep 1980;2:329–46.
Czeisler CA, Allan JS, Strogatz SH, Ronda JM, Sanchez R, Rios CD, Freitag WO, Richardson GS, Kronauer RE. Bright light resets the human circadian pacemaker independent of the timing of the sleep—wake cycle. Science 1986;233: 667–71.
Dantz B, Edgar DM, Dement WC. Circadian rhythms in narcolepsy: studies on a 90 minute day. Electroencephalogr Clin Neurophysiol 1994;90: 24–35.
DeKoninck J, Quera Salva M, Besset A, Billiard M. Are REM cycles in narcoleptic patients governed by an ultradian rhythm? Sleep 1986;9: 162–6.
Dement WC. The effect of dream deprivation. Science 1960;131: 1705–7.
Dijk DJ, Czeisler C. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neuroscience Letters 1994; 166: 63–8.
Dinges DF. Napping patterns and effects in human adults: In: Dinges DF, Broughton RJ, eds. Sleep and alertness: Chronobiological, behavioral and medical aspects of napping. New York: Raven Press, 1989:171–204.
Edgar DM, Dement WC, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep—wake regulation. J Neurosci 1993; 13:1065–79.
Folkard S. The pragmatic approach to masking. Chronobiology International 1988;6: 55–64.
Folkard S, Minors DS, Waterhouse JM. “Demasking” the temperature rhythm after simulated time zone transitions. J Biol Rhythms 1991;6:81–91.
Gagnon P, DeKoninck J, Broughton R. Reappearance of electroencephalogram slow waves in extended sleep with delayed bedtime. Sleep 1985;8: 118–28.
Ganado W. The narcolepsy syndrome. Neurology 1958;8: 487–96.
Gastaut H, Roth B. A propos des manifestations electroencephalographiques de 150 cas de narcolepsie avec ou sans cataplexie. Rev Neurol 1957;97: 388–97.
Gillberg M, Akerstedt T. Body temperature and sleep at different times of day. Sleep 1982;5: 378–88.
Godbout R, Montplaisir J. All day performance variations in normal and narcoleptic subjects. Sleep 1986;9: 200–4.
Gudewill S. Der Zusammenhang zwischen Schlaf-Wach-Verhalten und Hormonsekretion bei Narkolepsiepatienten. Doctoral Dissertation submitted to the Ludwig-Maximilians-Universität, Munich, Germany, 1992.
Hajek M, Meier-Ewert K, Wirz-Justice A, Tobler I, Arendt J, Dick H, Fink G. Bright white light does not improve narcoleptic symptoms. Eur Arch Psychiatr Neurol Sci 1989;238: 203–7.
Higuchi T, Takahashi Y, Takahashi K, Niimi Y, Miyasita A. Twenty-four-hour secretory patterns of growth hormone, prolactin and cortisol in narcolepsy. J Clin Endocrinol Metab 1979;49: 197–204.
Hishikawa Y, Wakamatsu H, Furuya E, Sugita Y, Masaoka S, Kaneda H, Sato M, Nan’no H, Kaneko Z. Sleep satiation in narcoleptic patients. Electroencephalogr Clin Neurophysiol 1976;41: 1–18.
Hildebrandt G. Grundlagen einer angewandten medizinischen Rhythmusforschung. Heilkunst, 1958;7: 117–36.
Honma K, Kohsaka M, Fukuda N, Morita N, Honma S. Effects of vitamin B12 on plasma melatonin rhythm in humans: Increased light sensitivity phase advances the circadian clock? Experientia 1992;48: 716–20.
Jouvet M. Recherches sur les structures nerveuses et les mechanismes responsables des differentes phases du animal physiologique. Arch Mol Biol 1962;100: 125–206.
Jouvet M. Paradoxical sleep mechanisms. Sleep 1994;17: S77–83.
Krieger DT. ed. Endocrine rhythms. Raven Press, NY, 1979.
Kripke DF. Biological rhythm disturbances might cause narcolepsy. In: Guilleminault C, Dement WC, Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976: 475–84.
Kripke DF, Lewis OF, Cook B. Sleep of night workers: EEG recordings. Psychophysiology 1971;7: 377–84.
Lavie P. Ultrashort sleep—waking schedule III. Gates and “forbidden zones” for sleep. Electroencephalogr Clin Neurophysiol 1985;63: 414–25.
Lavie P. Ultradian rhythms in arousal — the problem of masking. Chronobiology International 1989;6:21–8.
Lavie P. REM periodicity under ultrashort sleep/wake cycle in narcoleptic patients. Canadian Journal of Psychology 1991;45: 185–93.
Lavie P, Scherson A. Ultrashort sleep—waking schedule. I. Evidence of ultradian rhythmicity in’ sleepability.’ Electroencephalogr Clin Neurophysiol 1981;52: 163–74.
Mayer G, Sonnenschein W, Mittendorf K, Meier-Ewert K. The effects of vitamin B12 treatment on two narcoleptic patients under freerunning conditions. The 4th International Symposium on Narcolepsy, Tokyo 1994, Abstracts p. 39.
Middelkoop HAM, Lammers GJ, van Hilten BJ, Ruwhof C, Pijl H, Kamphuisen HAC. Circadian distribution of motor activity and immobility in narcolepsy: Assessment with continuous motor activity monitoring. Psychophysiology 1995;32, 286–91.
Mills JN, Minors DS, Waterhouse JM. Adaptation to abrupt time shifts of the oscillator(s) controlling human circadian rhythms. J Physiology 1978a;285: 455–70.
Mills JN, Minors DS, Waterhouse JM. The effect of sleep upon human circadian rhythms. Chronobiologia 1978b;5:14–27.
Minors DS, Waterhouse JM. Masking in humans: The problem and some attempts to solve it. Chronobiology International 1989;6: 29–53.
Montplaisir J. Disturbed nocturnal sleep. In: Guilleminault C, Dement WC and Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976:43–56.
Montplaisir J, Billiard M, Takahashi S, Bell IR, Guilleminault C, Dement WC. Twenty-four-hour recording in REM-narcoleptics with special reference to nocturnal sleep disruption. Biological Psychiatry 1978;13: 73–89.
Mosko SS, Holowach JB, Sassin JF. The 24-hour rhythm of core temperature in narcolepsy. Sleep 1983;6: 137–46.
Mullington J, Newman J, Dunham W, Broughton R. duration of naps in narcolepsy—cataplexy: Preliminary findings. In: Home J, ed. Sleep’ 90 Bochum: ontenagel Press, 1990: 158–60.
Mullington J, Broughton R. Scheduled naps in the management of daytime sleepiness in narcolepsy—cataplexy. Sleep 1993;16: 444–56.
Passouant P, Billiard M. The evolution of narcolepsy with age. In: Guilleminault C, Dement WC, Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976: 179–96.
Passouant P, Halberg F, Genicot R, Popoviciu L, Baldy-Moulinier M. La periodicite des acces narcoleptiques et le rhythme ultradien du sommeil rapide. Rev Neurolog 1969;121:155–64.
Pavel S, Goldstein R, Petrescu M. Vasotocin, melatonin and narcolepsy: possible involvement of the pineal gland in its patho-physiological mechanism. Peptides 1980;1:281–4.
Pollak CP, Wagner DW. Core body temperature in narcoleptic and normal subjects living in temporal isolation. Pharmacology Biochemistiy and Behavior 1994;47:65–71.
Pollak CP, Wagner DW, Moline M, Monk T. Cognitive and motor performance in narcoleptics and normals living in temporal isolation. Sleep 1992;15:202–11.
Pressman MR, Spielman AJ, Pollak CP, Weitzman E. Long-latency auditory evoked responses durcing sleep deprivation and in narcolepsy. Sleep 1982;5: S147–56.
Rechtschaffen A, Wolpert EA, Dement WC, Mitchell SA, Fisher C. Nocturnal sleep of narcoleptics. Electroencephalogr Clin Neurophysiol 1963;15:599–609.
Reiter RJ. Normal patterns of melatonin levels in the pineal gland and body fluids of humans and experimental animals. J Neural Transmission 1986;21: S35–54.
Richardson GS, Carskadon MA, Flagg W, Van den Hoed J, Dement WC, Mitler MM. Excessive daytime sleepiness in man: Multiple sleep latency measurements in narcoleptic and control subjects. Electroencephalogr Clin Neurophysiol 1978;45: 621–7.
Riou F, Gespuglio R and Jouvet M. Endogenous peptides and sleep in the rat. III. The hypnogogic properties of vasoactive intestinal polypeptide. Neuropeptides 1982;2: 265–77.
Roth B. The clinical and theoretical importance of EEG rhythms corresponding to states of lowered vigilance. Electroencephalogr Clin Neurophysiol 1961;13:395–9.
Roth B. Narcolepsy and Hypersomnia. Basel: Karger, 1980.
Schulz H. Ultradian rhythms in the nychthemeron of narcoleptic patients and normal subjects. In: Schulz H and Lavie P, eds. Ultradian rhythms in physiology and behavior. Berlin: Springer-Verlag, 1985:165–85.
Schulz H, Kiss E, Hasse S, Gudewill S, Lohr K, Brandenberger G, Follenius M, and Pollmacher T. The 24-h hormonal secretion pattern of narcoleptic patients and control subjects. In: J. Home, ed. Sleep’ 90. Bochum: Pontenagel Press, 1990:375–8.
Schulz H, Wilde-Frenz J, Simon O, Wever R, and Ruther E. Leep—wake rhythm in a narcoleptic patient under normal entrained conditions and during isolation from time cues. Sleep’ 82. Basel: Karger, 1983:336–8.
Schulz H, Wilde-Frenz J, Volk S and Geisler P. Narcolepsy and the pathological aspects of multiple napping. In: Stampi C, ed. Why we nap: Evolution, chronobiology and functions of polyphasic and ultrashort sleep. Boston: Birkhuser, 1992.
Scrima L. Isolated REM sleep facilitates recall of complex associative information. Psychophysiology 1982;19: 252–9.
Siegel JM, Fahringer HM, Anderson L, Nienhuis R, Gulyani J, Nassisi J, Mignot E, and Switzer RC. Evidence for localized neuronal degeneration in narcolepsy: studies in the narcoleptic dog. Sleep Research 1995;24:354.
Spielman AJ, Adler JM, Glovinsky PB, Pressmann MR, Thorpy MJ, Ellman SJ, and Ackerman KD. Dynamics of REM sleep in narcolepsy. Sleep 1986;9: 175–82.
Strogatz SH. The mathematical structure of the human sleep—wake cycle. Lecture notes in biomathmatics. Berlin: Springer-Verlag, 1986.
Tafti M, Rondouin G, Besset A and Billiard M. Sleep deprivation in narcoleptic subjects: effect on sleep stages and EEG power density. Electroencephalogr and Clin Neurophysiol 1992a;83:339–49.
Tafti M, Villemin E, Carlander B, Besset A and Billiard M. Sleep in human narcolepsy revisited with special reference to prior wakefulness duration. Sleep 1992b; 15:344–51.
Takahashi K, Takahashi Y, Takahashi S and Honda Y. Growth hormone and cortisol secretion during nocturnal sleep in narcoleptics and in dogs. In: Hatotani N, ed. Psychoneuroendocrinology. Basel: S Karger, 1974:67–76.
Takahashi Y, Takahashi K, Higuchi T, Niimi Y, Asita AM, and Ishii Y. Pituitary hormone secretions and narcolepsy. In: Guilleminault C, Dement WC, and Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976: 543–63.
Tsujimaru S, Satoh H, Egami H, Ida Y, Shirao I and Nakazawa Y. The facilitating effects of B12 on the re-entrainment of body temperature and locomotor activity rhythms to new light—dark cycle. Japanese J Psychiatry Neural 1991;45, 176–7.
Uchiyama M, Mayer G, Meier-Ewert K. Effects of the seasons on narcoleptic symptoms. Presented at the Sapporo Symposium on Biological Rhythms, Japan, August 25-29, 1993.
Uchiyama M, Mayer G, Meier-Ewert K. Differential effects of extended sleep in narcoleptic patients. Electroencephalogr Clin Neurophysiol 1994; 91: 212–18.
Valley V, Broughton RJ. Daytime performance deficits and physiological vigilance in untreated patients with narcolepsy—cataplexy compared to controls. Rev EEG Neurophysiol 1981; 11:133–9.
Valley V, Broughton RJ. The physiological (EEG) nature of drowsiness and its relation to performance deficits in narcoleptics. Electroencephalogr Clin Neurophysiol 1983;55:243–51.
Volk S, Schulz H, Yassouridis A, Wilde-Frenz J, Simon O. The influence of two behavioral regimes on the distribution of sleep and wakefulness in narcoleptic patients. Sleep 1990;13: 136–42.
Waldhauser F, Dietzel M. Daily and annual rhythms in human melatonin secretion: Role in puberty control. Annals NY Acad Sci 1985;453: 205–14.
Weitzman ED. Twenty-four hour neuroendocrine secretory patterns: Observations on patients with narcolepsy. In: Guilleminault C, Dement WC, Passouant P, eds. Narcolepsy. New York: Spectrum Publications, 1976: 521–42.
Weitzman ED, Kripke D, Goldmacher D, McGregor P, Nogeire C. Acute reversal of the sleep—waking cycle in man. Arch Neurol 1970;22:483–9.
Weitzman ED, Czeisler CA, Moore-Ede MC. Sleep—wake, neuroendocrine and body temperature circadian rhythms under entrained and non-entrained (free-running) conditions in man. In: Suda M, Hayaishi O, Nakagawa H, eds. Biological rhythms and their central mechanism. Amsterdam: Elsevier/North Holland Biomodical Press, 1979:199–227.
Wever R. The circadian system of man. Results of experiments under temporal isolation. New York: Springer-Verlag, 1979.
Yamazaki J, Sugishita M, Moriya Y, Isojima G, Ohshima H, Yamazaki O, Takeda Y, Yamauchi T, Takashima M, and Takahashi K. The effects of Vitamin B12 on the suppression of melatonin secretion under illumination. Japanese Journal Psychiatry Neurol 1991;45, 169–70.
Zulley J, Bailer J. Polyphasic sleep/wake patterns and their significance to vigilance. In: Nachreiner F, ed. Studies in industrial and organization psychology. Frankfurt: Verlag Peter Lang, 1988:167–80.
Zulley J, Campbell S. Napping behavior during “spontaneous internal desynchronization”: Sleep remains in synchrony with body temperature. Human Neurobiology 1985;4: 123–6.
Zulley J, Wever R, and Aschoff J. The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature, Pflügers Arch 1981;391: 314–18.
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Mullington, J., Broughton, R. (1997). Does a Chronobiologic Defect Exist in Narcolepsy?. In: Meier-Ewert, K., Okawa, M. (eds) Sleep—Wake Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0245-0_10
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