Pharmacokinetic — Pharmacodynamic Relationships

  • Pierre Canal
  • Etienne Chatelut

Abstract

Research of relationships between pharmacokinetics and pharmacodynamics in clinical oncology should result in a better use of anticancer drugs. The goal of these approaches is to improve cancer chemotherapy by optimising drug therapy in individual patients. After some recalls about general principles of pharmacokinetics and pharmacodynamics, the different models used for analysing pharmacokinetics-pharmacodynamics relationships will be defined. Before considering the different methods of adaptive dosing of anticancer drugs, the different reasons of variability in pharmacokinetics will be described briefly.

Keywords

Anticancer Drug Therapeutic Drug Monitoring Plasma Protein Binding Platinum Compound Platelet Nadir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Pierre Canal
    • 1
  • Etienne Chatelut
    • 1
  1. 1.Pharmacology LaboratoryCentre Claudius RegaudToulouse CedexFrance

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