Molecular Dynamics Simulations of Cisplatin Adducts with Dinucleotides
Whereas the molecular basis for the antitumor activity of cisplatin is not yet established, there are numerous experimental results implicating DNA binding in the antitumor mechanism. Whatever happens between platinum binding to DNA and the cell death, the hypothesis that the structural distortion plays a role in the processing of the Pt-DNA adducts does not seem unlikely, and provides the pharmacological motivation for structural studies on these adducts.
KeywordsMolecular Dynamic Simulation Numerous Experimental Result Molecular Mechanic Simulator Platinum Binding Nonbonded Energy
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