Molecular Dynamics Simulations of Cisplatin Adducts with Dinucleotides

  • Jiří Kozelka


Whereas the molecular basis for the antitumor activity of cisplatin is not yet established, there are numerous experimental results implicating DNA binding in the antitumor mechanism. Whatever happens between platinum binding to DNA and the cell death, the hypothesis that the structural distortion plays a role in the processing of the Pt-DNA adducts does not seem unlikely, and provides the pharmacological motivation for structural studies on these adducts.


Molecular Dynamic Simulation Numerous Experimental Result Molecular Mechanic Simulator Platinum Binding Nonbonded Energy 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Jiří Kozelka
    • 1
  1. 1.Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400CNRS, Université René DescartesParis 06France

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