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Hypersensitivity to Cisplatin in Mouse Leukemia L1210/0 Cells: An XPG DNA Repair Defect

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2

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Abstract

A major limitation to the clinical efficacy of cisplatin is the intrinsic or acquired resistance of many neoplasms to the drug. As a result, many studies to investigate the mechanisms of cisplatin resistance have been carried out with human and rodent cells in culture. Acquired resistance has been ascribed in different cases to changes in drug accumulation, intracellular drug inactivation by enhanced levels of glutathione or metallothionein, and enhanced DNA repair.

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Author information

Author notes

  1. Juhani A. Vilpo & Leena M. Vilpo

    Present address: Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland

  2. David E. Szymkowski

    Present address: Roche Research Centre, Welwyn Garden City, AL7 3AY, UK

  3. Anne O’Donovan

    Present address: Amersham International, Cardiff, CF4 7YT, UK

Authors and Affiliations

  1. Clare Hall Laboratories, Imperial Cancer Research Fund, South Mimms, Herts, EN6 3LD, UK

    Richard D. Wood, Juhani A. Vilpo, Leena M. Vilpo, David E. Szymkowski, Anne O’Donovan & Jonathan G. Moggs

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  1. Richard D. Wood
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  2. Juhani A. Vilpo
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  3. Leena M. Vilpo
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  4. David E. Szymkowski
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  5. Anne O’Donovan
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  6. Jonathan G. Moggs
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Editor information

Editors and Affiliations

  1. Free University, Amsterdam, The Netherlands

    H. M. Pinedo

  2. Netherlands Cancer Institute, Amsterdam, The Netherlands

    J. H. Schornagel

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© 1996 Springer Science+Business Media New York

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Wood, R.D., Vilpo, J.A., Vilpo, L.M., Szymkowski, D.E., O’Donovan, A., Moggs, J.G. (1996). Hypersensitivity to Cisplatin in Mouse Leukemia L1210/0 Cells: An XPG DNA Repair Defect. In: Pinedo, H.M., Schornagel, J.H. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0218-4_30

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  • DOI: https://doi.org/10.1007/978-1-4899-0218-4_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0220-7

  • Online ISBN: 978-1-4899-0218-4

  • eBook Packages: Springer Book Archive

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