Iminoethers as Carrier Ligands: A Novel trans-Platinum Complex Possessing in Vitro and in Vivo Antitumour Activity

  • Mauro Coluccia
  • Maria A. Mariggiò
  • Angela Boccarelli
  • Francesco Loseto
  • Nicola Cardellicchio
  • Paola Caputo
  • Francesco P. Intini
  • Concetta Pacifico
  • Giovanni Natile


The platinum-based anticancer drug cis-[PtCl2(NH3)2] (cis-DDP) is one of the most effective drugs available for the treatment of human tumours,1 whereas its trans isomer (trans-DDP) is inactive.2–6 The clinical efficacy of cis-DDP is, however, limited by tumour cell resistance present either in the onset of treatment (intrinsic) or after an initial response (acquired)7 Cis-DDP resistance appears to be mediated by factors which reduce platinum-DNA adduct formation, e.g. reduced intracellular accumulation, increased inactivation by intracellular thiols, increased repair8 or tolerance of platinum-DNA adducts.9


Trans Isomer Platinum Complex Interstrand Crosslinks Planar Ligand Trans Geometry 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mauro Coluccia
    • 1
  • Maria A. Mariggiò
    • 1
  • Angela Boccarelli
    • 1
  • Francesco Loseto
    • 1
  • Nicola Cardellicchio
    • 3
  • Paola Caputo
    • 2
  • Francesco P. Intini
    • 2
  • Concetta Pacifico
    • 2
  • Giovanni Natile
    • 2
  1. 1.Dipartimento di Scienze Biomediche e Oncologia UmanaUniversità di BariBariItaly
  2. 2.Dipartimento Farmaco-ChimicoUniversità di BariBariItaly
  3. 3.CNRIstituto Sperimentale TalassograficoTarantoItaly

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