Phase I Trials of Ormaplatin (NSC 363812)

  • Michaele C. Christian


Tetrachloro(d,l-trans)1,2-diaminocyclohexaneplatinum (IV), ormaplatin (OP), NSC 363812, formerly called tetraplatin, is a second generation platinum (IV) compound which has been evaluated in clinical trials sponsored by the National Cancer Institute (NCI) in collaboration with Upjohn. Interest in this group of compounds was stimulated by structure-activity studies by Burchenal et al.,(1) which suggested that platinum compounds containing the 1,2-diaminocyclohexane (DACH) carrier ligand retained activity in vitro and in vivo against L1210 and P388 murine leukemia cell lines with acquired resistance to cisplatin. In addition, in preclinical antitumor testing, OP demonstrated broad spectrum activity comparable to or superior to cisplatin (CDDP) against a variety of murine and human tumor models (2,3) however, its activity in other models was variable and against a screening panel of 16 human ovarian cancer cell lines was disappointing (4).


Sural Nerve Human Ovarian Cancer Cell Line Total Platinum Ultrafilterable Platinum Prophylactic Antiemetic 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Michaele C. Christian
    • 1
  1. 1.Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer TreatmentNational Cancer InstituteBethesdaUSA

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