NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids

  • Kevin J. Barnham
  • Susan J. Berners-Price
  • Zijian Guo
  • Piedad del Socorro Murdoch
  • Peter J. Sadler


In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.


Platinum Complex Platinum Drug Chemical Shift Anisotropy Amine Complex Diferric Transferrin 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kevin J. Barnham
    • 1
  • Susan J. Berners-Price
    • 2
  • Zijian Guo
    • 1
  • Piedad del Socorro Murdoch
    • 1
  • Peter J. Sadler
    • 1
  1. 1.Department of Chemistry, Birkbeck CollegeUniversity of London, Gordon House and Christopher Ingold LaboratoriesLondonUK
  2. 2.School of ScienceGriffith UniversityNathan, BrisbaneAustralia

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