Abstract
Over-stimulation of glutamate receptors and oxidative stress are two possible mechanisms that cooperate to selective degeneration of dopaminergic cells in Parkinson’s Disease (PD)1,2,3. Defects in mitochondrial enzymes, which make dopaminergic cells more susceptible to oxidative stress, have been found not only in substantia nigra of PD patients4, but also in their peripheral tissues5and blood platelets6,7,8,9. Recent studies also indicated that impaired mitochondrial function in platelets of PD patients is a characteristic of the disease and is not a consequence of pharmacological treatment10.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M.F. Beal, Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?, Ann Neurol. 31:119 (1992).
S. Fahn and G. Cohen, The oxidant stress hypothesis in Parkinson’s disease: evidence supporting it, Ann Neurol 32:804 (1992).
J.T. Coyle and P. Puttfarcken, Oxidative stress, glutamate, and neurodegenerative disorders, Science. 262:689 (1993).
N. Hattori, M. Tanaka, T. Ozawa and Y. Mizuno, Immunohistochemical studies on Complexes I, II, III and IV of mithocondria in Parkinson’s disease, Ann Neurol. 30:563 (1991).
J.M. Shoffner, R.L. Watts, J.L. Juncos, A. Torroni and D.C. Wallace, Mitochondrial oxidative phosphorylation defects in Parkinson’s disease, Neurology. 41 suppl 1:152 (1991).
W.D. Parker, S.J. Boyson and J.K. Parks, Abnormalities of the electron transport chain in idiopathic Parkinson’s disease, Ann Neurol. 26:719 (1989).
D. Krige, M.T. Carroll, J.M. Cooper, C.D. Marsden and A.H.V. Schapira, Platelet mithocondrial function in Parkinson’s disease, Ann Neurol. 32:782 (1992).
H. Yoshino, Y Nakagawa-Hattori, T Kondo and Y Mizuno, Mitochondrial complex I and II activities and platelets in Parkinson’s disease, J Neural Transm. 4:27 (1992).
R. Benecke, P. Strumper and H Weiss, Electron transfer complexes I and IV of platelets are abnormal in Parkinson’s disease but normal in Parkinson-plus syndromes, Brain. 116:1451 (1993).
C.W. Shults, F. Nasirian, D.M. Ward, K. Nakano, M. Pay, L.R. Hill and R.H. Haas, Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early parkinsonism, Neurology. 45:344 (1995).
A. Barbeau, G. Campanella, R.F. Butterworth and K. Yamada, Uptake and efflux of 14C-dopamine in platelets: evidence for a generalized defect in Parkinsons’s disease, Neurology. 25:1 (1975).
J. M. Rabey, H. Shabtai, E. Graff and Z. Oberman, [3H] dopamine uptake by platelet transport chain in idiopathic Parkinson’s disease, Life Sci. 3:1753 (1993).
R.M. Mangano and R. Schwarcz, The human platelet as a model for the glutamatergic neuron: platelet uptake of L-glutamate, J Neuropathol. 36:1067 (1981).
M.M. Hoehn and M.D. Yahr, Parkinsonism: onset, progression and mortality, Neurology. 17:427 (1967).
S. Fahn, R.L. Elton and The Members of the UPDRS development committee, Unified Parkinson’s disease rating scale, in: “Recent Develpments in Parkinson’s disease,” S. Fhan, D. Marsden and D. Calne ed., MacMillan, London (1987).
M.F. Folstein, S.E. Folstein and P.R. McHugh, “Mini-Mental State”: a pratical method for grading the cognitive state of patients for the clinician, J Psychiatr Res. 12:189 (1975).
C. Ferrarese, N. Pecora, M. Frigo, I. Appollonio and L. Frattola, Assessment of reliability and biological significance of glutamate levels in cerebrospinal fluid, Ann Neurol 33:316 (1993).
R. Joseph, C. Tsering, S. Grunfeld, and K.M.A. Welch, Platelet secretory products may contribute to neuronal injury, Stroke. 22:1448 (1991).
S. Murphy, S. Munoz, M. Parry-Billings, and E. Newsholme, Amino acid metabolism during platelet storage for transfusion, Br J Stroke. 81:585 (1992).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ferrarese, C. et al. (1996). Platelets as Peripheral Model of Glutamate-Related Excitotoxicity in Parkinson’s Disease. In: Fiskum, G. (eds) Neurodegenerative Diseases. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0209-2_9
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0209-2_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0211-5
Online ISBN: 978-1-4899-0209-2
eBook Packages: Springer Book Archive