Potential Role of Hyperactivation of Signal Transduction Pathways in Alzheimer’s Disease: Protein Kinase C Regulates PHF-like Phosphorylation of Tau within Neuronal Cells

  • Thomas B. Shea
  • John J. Boyce
  • Corrine M. Cressman
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Paired helical filaments (PHF) that accumulate in affected neurons in Alzheimer’s disease are comprised of hyperphosphorylated tau that exhibits electrophoretic and antigenic properties distinct from that of normal adult CNS tau (for reviews, see refs. 1–3). Accordingly, one approach towards understanding the onset and progression of Alzheimer’s disease is to determine the kinase(s) responsible for phosphorylating tau.


Calpain Activation Calpain Inhibitor Paired Helical Filament Calcium Ionophore A23187 Paired Helical Filament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Thomas B. Shea
    • 1
    • 2
  • John J. Boyce
    • 1
    • 2
  • Corrine M. Cressman
    • 1
  1. 1.Center for Cellular Neurobiology and Neurodegeneration ResearchUniversity of Massachusetts at LowellLowellUSA
  2. 2.Department of Biological SciencesUniversity of Massachusetts at LowellLowellUSA

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