Biochemical Characteristics of Oxygen-Induced and Low K+ Medium-Induced Apoptotic Neuronal Death

  • Yasushi Enokido
  • Takekazu Kubo
  • Noboru Sato
  • Yasuo Uchiyama
  • Hiroshi Hatanaka
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)

Abstract

Neuronal cell death is thought to be an important phenomenon not only in the developmental but also in the post-matured stages of PNS and CNS. In the developmental stages, massive neuronal death is observed at specific periods, e.g. the immediately after the arrival of axons to the postsynaptic target fields. This phenomenon is precicely programmed in the developing nervous system and called programmed (or apoptotic) neuronal death. Recent studies also suggest that similer apoptotic neuronal death occurs in the matured nervous system, e.g. neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, and aging. Thus, it is expected that the study of apoptosis in the nervous system give us useful clues to know how the neuronal net work are constructed in the development and why the neurodegenerateve diseases and brain aging occur.

Keywords

PC12 Cell Neuronal Death Cerebellar Granule Neuron Prevent Cell Death Apoptotic Neuronal Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Y. Enokido and H. Hatanaka, Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere., Neuroscience, 57:965 (1993).PubMedCrossRefGoogle Scholar
  2. 2.
    T. Kubo, T. Nonomura, Y. Enokido and H. Hatanaka, Brain-derived neurotrophic factor (BDNF) can protect apoptotis of rat cerebellar granule neurons in culture., Dev. Brain Res, 85:249 (1995).CrossRefGoogle Scholar
  3. 3.
    N. Sato, K. Hotta, S. Waguri, T. Nitatori, K. Tohyama, Y. Tsujimoto and Y. Uchiyama, Neuronal differentiation of PC12 cell as a result of prevention of cell death by bcl-2., J. Neurobiol., 25:1227 (1994).PubMedCrossRefGoogle Scholar
  4. 4.
    M.B. Hansen, S.E. Nielsen and K. Berg, Re-examination and further development of aprecice and rapid dye method for measureing cell growth/cell kill., J. Immunol. Methods, 119:203 (1989).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yasushi Enokido
    • 1
  • Takekazu Kubo
    • 1
  • Noboru Sato
    • 2
  • Yasuo Uchiyama
    • 2
  • Hiroshi Hatanaka
    • 1
  1. 1.Division of Protein Biosynthesis Institute for Protein ResearchOsaka UniversityOsaka, 565Japan
  2. 2.1st Department of AnatomyOsaka University school of MedicineOsaka, 565Japan

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