Neuronal Differentiation of PC12 Cells in the Absence of Extracellular Matrix Adhesion Induces Apoptosis
Part of the
GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia
book series (GWUN)
In recent years, evidence has accumulated implicating programmed cell death as a major mechanism underlying neurodegenerative processes. Programmed cell death has been described in a wide range of cell types in response to diverse factors including steroids, cytokines, ionizing radiation, virus infection, and many other agents1. It is an active process that is often dependent on RNA and protein synthesis and probably involves a number of complex pathways that ultimately result in endonuclease activation, DNA fragmentation, and cell death. Programmed cell death may be distinguished form “accidental” cell death that results from hypoxia, trauma, or toxic agents, although all of these processes may involve common pathways2. In the brain, programmed cell death has been well established as a part of normal development3, following excitotoxic death of targets of innervation4, and as a consequence of amyloid toxicity5,6. These findings suggest that programmed cell death may be a central common pathway in numerous neurodenegerative processes including Alzheimer’s disease. This concept is supported by observations that neurons are strictly dependent on growth factors to prevent programmed cell death and promote survival7 and by evidence that growth factor response mechanisms are attenuated in aging8.
KeywordsPC12 Cell Nerve Growth Factor Programme Cell Death Focal Adhesion Kinase Matrix Adhesion
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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