Ciliary Neurotrophic Factor (CNTF): Possible Implications in the Pathogenesis of Amyotrophic Lateral Sclerosis

  • Richard W. Orrell
  • Russell J. M. Lane
  • Jackie S. de Belleroche
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, primarily affecting both upper and lower motor neurons. The median age of onset is around 68 years, and median survival approximately 2 years, although with significant variability1. The pathogenesis is unknown, but the recognition of mutations in the gene for copper/zinc Superoxide dismutase (SOD-1)2 in a proportion of patients (around 1–2% of all cases), almost all of whom have a family history of the condition, has provided fruitful avenues of research3. Nevertheless, the mechanism by which these mutations lead to the expression of the disease is not yet established4,5.

Keywords

Amyotrophic Lateral Sclerosis Motor Neuron Nerve Growth Factor Motor Neuron Disease Lower Motor Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Richard W. Orrell
    • 1
    • 2
  • Russell J. M. Lane
    • 2
  • Jackie S. de Belleroche
    • 1
  1. 1.Department of BiochemistryCharing Cross and Westminster Medical SchoolLondonEngland
  2. 2.Academic Unit of NeuroscienceCharing Cross and Westminster Medical SchoolLondonEngland

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