Intracellular Calcium Stores and Ischemic Neuronal Death

  • David C. Perry
  • Huafeng Wei
  • Wenlin Wei
  • Dale E. Bredesen
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Disruption of cellular regulation of calcium has long been implicated in the mechanism of neruonal death following cerebral ischemia and reperfusion9,17. While much research has been directed at the potential role of calcium influx in ischemia, less attention has been paid to other mechanisms of calcium regulation that may be altered. We are investigating the possibility that altered storage and release of Ca2+ from the endoplasmic reticulum (ER) contributes to ischemic neuronal death.


Ryanodine Receptor Sham Control Global Cerebral Ischemia Inositol Trisphosphate Intracellular Calcium Store 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • David C. Perry
    • 1
  • Huafeng Wei
    • 1
  • Wenlin Wei
    • 1
  • Dale E. Bredesen
    • 2
  1. 1.Department of PharmacologyThe George Washington University Medical CenterUSA
  2. 2.Program on AgingThe La Jolla Cancer Research FoundationLa JollaUSA

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