Oxidative Stress Plays a Role in the Pathogenesis of Familial and Sporadic Amyotrophic Lateral Sclerosis

  • Catherine Bergeron
  • Connie Petrunka
  • Luitgard Weyer
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the selective death of upper and lower motorneurons. The disease affects 0.6–2.6:100,000 individuals1, with a mean age at onset of approximately 55 and a duration of two to three years on average2. Motorneuron death results in muscle weakness and paralysis with eventual ventilatory failure and death.


Superoxide Dismutase Amyotrophic Lateral Sclerosis Motor Neuron Disease Sporadic Amyotrophic Lateral Sclerosis Familial Amyotrophic Lateral Sclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Catherine Bergeron
    • 1
    • 2
  • Connie Petrunka
    • 1
  • Luitgard Weyer
    • 1
  1. 1.Centre for Research in Neurodegenerative Diseases and Department of PathologyUniversity of TorontoTorontoCanada
  2. 2.Department of PathologyThe Toronto HospitalTorontoCanada

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