The Protective Action of Nitrone-Based Free Radical Traps in Neurodegenerative Diseases
Nitrone-based free radical traps (NRTs) have been shown to protect in several experimental animal models of neurodegenerative diseases and to mitigate other parameters associated with the aging process in brain. Since the prototype NRTs were first utilized in analytical chemistry to trap and characterize the presence of free radicals in chemical and biochemical systems, it is the simplest hypothesis that they protect by trapping crucial free radicals involved in the oxidative damage that occurs in animal models of neurodegenerative diseases. This remains to be rigorously proven. Pertinent data supporting this concept are presented in a framework of the knowledge accrued from studies on oxidative damage in brain.
KeywordsElectron Spin Resonance Middle Cerebral Artery Occlusion Multiple System Atrophy Infarct Volume Cerebellar Granule Cell
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