Modulation of Vesicular Glutamate Release during Anoxia

  • Norman Hershkowitz
  • Alexander N. Katchman
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Despite the fact that stroke is a leading cause of morbidity and mortality, there is very little the clinician has to offer for its acute management. Clarification of the mechanisms that contribute to cell death during hypometabolic states such as stroke and anoxia may lead to novel strategies for therapy. It appears that excitatory amino acids (glutamate and aspartate) released during stroke contribute to the resulting neuronal death through the mechanism of excitotoxicity1,2. However, the mechanism of this release and its regulation are poorly understood.


Glutamate Release Excitatory Postsynaptic Current Inhibitory Postsynaptic Current Vesicular Release Intracellular Calcium Mobilization 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Norman Hershkowitz
    • 1
  • Alexander N. Katchman
    • 1
  1. 1.Department of NeurologyGeorgetown University Medical SchoolUSA

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