α-Ketoglutarate Dehydrogenase in Alzheimer’s Disease

  • John P. Blass
  • Kwan-Fu Rex Sheu
  • Rudolph E. Tanzi
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


Since ancient times, a creative tension has existed between two viewpoints on illness. One, associated with the Platonic physicians of the island of Cnos, looks on diseases as specific entities which can be classified like plants. From this viewpoint, the specific patient in the examining room is a more or less close copy of an idealized patient. In modern times, this view was developed with particular strength by Sydenham in London in the 1600s. The second viewpoint, associated with the Hippocratic physicians of the island of Cos, views illness as occurring when an organism can no longer remain in balance with the challenges of its environment. In modern times, this view was put forward with particular clarity by Claude Bernard in Paris in the 1800s. He emphasized that an illness occurs when living organisms cannot maintain their “milieu interne” in the face of the challenges of their environment.


Oxidative Metabolism Amyloid Precursor Protein ApoE Gene Culture Skin Fibroblast Selective Vulnerability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • John P. Blass
    • 1
  • Kwan-Fu Rex Sheu
    • 1
  • Rudolph E. Tanzi
    • 2
  1. 1.Altschul Laboratory for Dementia Research and Will Rogers Institute, Burke Medical Research InstituteCornell University Medical CollegeWhite PlainsUSA
  2. 2.Neurogenetics Laboratory and Laboratory of Genetics and AgingMassachusetts General Hospital, Harvard Medical SchoolBostonUSA

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