RNA Message Levels in Normally Aging and in Alzheimer’s Disease(AD)-Affected Human Temporal Lobe Neocortex
The expression of genetic information in neurons and glia, as in all eukaryotic cells, is dependent upon a hierarchy of control, from the acquisition of a transcriptionally competent chromatin conformation to the final assembly and compartmentalization of the relevant gene products. As outlined in Table 1, this genetic signal transduction pathway from DNA to RNA to protein can be further categorized into a series of control gates involving DNA transcription and other post-transcriptional aspects of gene regulation (1–6) and (b) a series of translational and post-translational control points (8–12); the shuttling of RNA messages out of the nucleus and into the cytoplasm represents one prominent intermediary control point (7). Amongst the eukaryotic cells, neurons of the mammalian brain appear to be unique in that the rate of genetic information flow through these control gates appears to be particularly rapid1, and both quantitatively and qualitatively large amounts of brainspecific DNA transcription products are generated1,2.
KeywordsGrowth Inhibitory Factor Primary Gene Product Temporal Lobe Neocortex Numerous Senile Plaque Packard Instant Imager
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