Eicosanoids pp 13-20 | Cite as

Lipoxygenases of Mice and Men

  • Colin D. Funk
Part of the NATO ASI Series book series (NSSA, volume 283)


Seven years have elapsed since the cloning of the cDNA for the first mammalian lipoxygenase and the deduced primary structure (Matsumoto et al., 1988; Dixon et al., 1988). Here, a brief comparative overview of the molecular properties of human and mouse lipoxygenases will be presented. Although each of the human lipoxygenases were isolated and systematically characterized prior to the corresponding murine homologs it became necessary to evaluate their relatedness in view of our present targeted lipoxygenase gene inactivation experiments in mice.


Nuclear Envelope Human Embryonic Kidney Human Alveolar Macrophage Murine Homolog Target Gene Disruption 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Colin D. Funk
    • 1
  1. 1.Division of Clinical PharmacologyVanderbilt University School of MedicineNashvilleUSA

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