Eicosanoids pp 165-182 | Cite as

Leukotriene Antagonists and Synthetase Inhibitors; Clinical Applications in the Treatment of Bronchial Asthma

  • G. C. Folco
  • C. Buccellati
  • T. Testa
  • M. Bolla
  • A. Sala
Part of the NATO ASI Series book series (NSSA, volume 283)


Asthma is a complex disease with the following characteristics: (1) airway obstruction that is reversible (but not completely so in some patients) either spontaneously or with treatment; (2) airway inflammation; and (3) increased airway responsiveness to a variety of stimuli (National Heart, Lung, and Blood Institute; National Asthma Education Program; Guidelines for the diagnostic and management of asthma, March 11, 1991). Recent observations in both human subjects and animal models suggest that the abnormalities of asthma are manifestations of airway inflammation that is a key factor even in patients with asthma at a clinically early stage (Laitinen et al., 1993).


Asthmatic Subject Late Asthmatic Response Eicosatetraenoic Acid Human Bronchus LTA4 Hydrolase 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • G. C. Folco
    • 1
  • C. Buccellati
    • 1
  • T. Testa
    • 1
  • M. Bolla
    • 1
  • A. Sala
    • 1
  1. 1.Center for Cardiopulmonary Pharmacology, Institute of Pharmacological SciencesUniversity of MilanMilanItaly

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