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Receptors and Second Messengers for Cys-Leukotrienes

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Eicosanoids

Part of the book series: NATO ASI Series ((NSSA,volume 283))

Abstract

It is well known that leukotrienes (LTs) can be divided into two classes, which differ for both the chemical structure and the pattern of biological activities: one class encompasses LTB4 only, an hydroxyacid that, mainly by means of its chemotactic action, plays a fundamental role in inflammation. The second class comprises LTC4, LTD4 and LTE4, cysteine containing leukotrienes (Cys-LTs), which can be interconverted into one another. They are potent smooth muscle constrictors, cause mucus hypersecretion in the airways and contribute to the onset of inflammation by their ability to cause plasma extravasation. Given these differences, it is not unexpected that, although both classes have been demonstrated to elicit their actions through the interaction with specific receptors, the receptors for LTB4 are totally different from those for Cys-LTs and no cross-reactivity has been shown among the two classes.

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Authors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, via Balzaretti, 9, Milan, Italy

    S. Nicosia, V. Capra, M. R. Accomazzo, E. Galbiati, D. Ragnini, R. Saponara, S. Novarini & G. E. Rovati

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  1. S. Nicosia
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  2. V. Capra
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  3. M. R. Accomazzo
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  4. E. Galbiati
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  5. D. Ragnini
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  6. R. Saponara
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  7. S. Novarini
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  8. G. E. Rovati
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    Gian Carlo Folco

  2. Karolinska Institute, Stockholm, Sweden

    Bengt Samuelsson

  3. Hôpital Lariboisére, Paris, France

    Jacques Maclouf

  4. University of Verona Medical School, Verona, Italy

    G. P. Velo

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© 1996 Springer Science+Business Media New York

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Nicosia, S. et al. (1996). Receptors and Second Messengers for Cys-Leukotrienes. In: Folco, G.C., Samuelsson, B., Maclouf, J., Velo, G.P. (eds) Eicosanoids. NATO ASI Series, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0200-9_13

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  • DOI: https://doi.org/10.1007/978-1-4899-0200-9_13

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