Eicosanoids pp 117-125 | Cite as

N-3 Fatty Acids. Antithromboxane Activity. Effects on Redox Status of Blood Cells

  • M. Lagarde
  • M. Croset
  • E. Véricel
  • G. C. Le Breton
  • A. F. Prigent
  • C. Calzada
Part of the NATO ASI Series book series (NSSA, volume 283)


N-3 fatty acids are polyunsaturated ones that all derive from linolenic acid (18:3n-3) in animals. Together with linoleic acid (18:2n-6), that cannot be synthesized in animals, 18:3n-3 is considered as an essential fatty acid, especially in being the precursor of docosahexaenoic acid (DHA or 22:6n-3), the main polyunsaturated fatty acid (PUFA) of the cerebrovascular system (Salem, 1989). A great interest in n-3 fatty acids also consists in their ability to slow down the arachidonic acid cascade in blood and vascular cells, resulting in a potential prevention of cardiovascular diseases (Leaf & Weber, 1988). The present article will focus on the antithromboxane activity of n-3 fatty acids from marine oil and on their effects as prooxidant/antioxidant molecules.


Arachidonic Acid Human Platelet Arachidonic Acid Cascade Prostaglandin Endoperoxide Phospholipid Transfer Protein 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. Lagarde
    • 1
  • M. Croset
    • 1
  • E. Véricel
    • 1
  • G. C. Le Breton
    • 1
    • 2
  • A. F. Prigent
    • 1
  • C. Calzada
    • 1
  1. 1.Chimie Biologique INSA-LyonINSERM U352VilleurbanneFrance
  2. 2.Department of PharmacologyUniversity of IllinoisChicagoUSA

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