Abstract
Isoprostanes represent a newly characterized family of vasoactive eicosanoids that are formed by a non-cyclooxygenase, free radical-catalyzed mechanism involving peroxidation of arachidonic acid (Morrow et al, 1990). One of these compounds is 8-epi-PGF2α which has attracted considerable attention because of its biological activity. 8-epi-PGF2α is a potent vasoconstrictor in the rat and its action is mediated, at least in part, through the vascular PGH2/TXA2 receptor (Takahashi et al., 1992). Moreover, 8-epi-PGF2α induces platelet shape change but not aggregation (Morrow et al., 1992).
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Ciabattoni, G. et al. (1996). Studies of Isoprostane Biosynthesis in Man. In: Folco, G.C., Samuelsson, B., Maclouf, J., Velo, G.P. (eds) Eicosanoids. NATO ASI Series, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0200-9_11
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