Eicosanoids pp 105-109 | Cite as

Platelet-Activating Factor Regulates Events at the Vascular Wall

  • Stephen M. Prescott
  • Thomas M. McIntyre
  • Guy A. Zimmerman
Part of the NATO ASI Series book series (NSSA, volume 283)


Leukocytes must bind to endothelium and migrate into tissues to defend us (for example, against bacterial infection)—the process of physiological inflammation (Zimmerman et al., 1992b). On the other hand, if the activation of leukocytes occurs at the wrong time or place, then pathological changes result. For example, the activation of neutrophils within the blood stream underlies various forms of vascular injury such as the Acute Respiratory Distress Syndrome and reperfusion injury. Additionally, the accumulation of monocytes, and their conversion to macrophages, in the vascular wall is a key feature of atherosclerosis. We have studied the molecular events that regulate adhesion and activation in an in vitro model of these events.


Endothelial Cell Acute Respiratory Distress Syndrome Endothelial Cell Surface Adherent Leukocyte Endothelial Cell Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Stephen M. Prescott
    • 1
  • Thomas M. McIntyre
    • 1
  • Guy A. Zimmerman
    • 1
  1. 1.The Nora Eccles Harrison Cardiovascular Research & Training Institute, Departments of Internal Medicine and BiochemistryUniversity of UtahSalt Lake CityUSA

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