Oxidative Stress-Induced Cell Damage in the CNS

A Proposal for a Final Common Pathway
  • Sara J. Robb-Gaspers
  • James R. Connor


The previous chapters in this book have reviewed the involvement of transition metals in diseases of the central nervous system. While each of the diseases described was unique in its symptoms, one common feature is present: Transition metals contribute to the pathological process by facilitating generation of reactive oxygen species (ROS). This concluding chapter will examine the cells and organelles at risk for oxidative damage and propose a final common pathway in neural pathogenesis of oxidative stress.


Nitric Oxide Amyotrophic Lateral Sclerosis Brain Mitochondrion Pyridine Nucleotide Final Common Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Sara J. Robb-Gaspers
    • 1
  • James R. Connor
    • 1
  1. 1.George M. Leader Family Laboratory for Alzheimer’s Disease Research, Department of Neuroscience and AnatomyPennsylvania State University College of Medicine, M. S. Hershey Medical CenterHersheyUSA

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