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Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury Directions for Therapeutic Intervention

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Metals and Oxidative Damage in Neurological Disorders

Abstract

When placental or pulmonary gas exchange is compromised in the fetus or newborn infant it produces hypoxemia, hypercapnia, and metabolic acidosis. Initially during asphyxia, blood flow to the brain increases to maintain cerebral energy metabolism until cardiac depression causes hypotension, bradycardia, and cerebral ischemia (Van-nucci, 1990). Unless prompt and effective resuscitation is achieved, the asphyxiated infant will die. Even when resuscitation is successful, survival may be accompanied by varying degrees of brain injury, the nature of which is related to the duration of the primary insult, the gestational age, and therapeutic interventions initiated during the post-resuscitation period.

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  1. Division of Newborn Medicine, Department of Pediatrics, M. S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, 17033, USA

    Charles Palmer

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  1. Pennsylvania State University, Hershey, Pennsylvania, USA

    James R. Connor

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Palmer, C. (1997). Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury Directions for Therapeutic Intervention. In: Connor, J.R. (eds) Metals and Oxidative Damage in Neurological Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0197-2_12

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