The history of vitamin E dates back to 1922 when Evans and Bishop (1922) discovered it as a nutritional factor that prevented resorption of the fetus in the laboratory rat. Since then innumerable investigations have been conducted to understand the role of vitamin E in maintaining the structure and function of various tissues. A few years ago this author reviewed selected aspects of the neurochemistry of vitamin E (Vatassery, 1992). The current article is intended to describe the state of the art with respect to the neurobiology of vitamin E, with special emphasis on human neurological diseases. The last section of the chapter summarizes part of the work done in our laboratory. During the last few years many new studies have appeared on this subject. The goal of the current review is not to present a comprehensive review of the field but to highlight some of the new information that has appeared in the literature.
KeywordsTardive Dyskinesia Alpha Tocopherol Passive Avoidance Response Gamma Tocopherol Linoleic Acid Hydroperoxide
Unable to display preview. Download preview PDF.
- Ben Hamida, M., Belal, S., Sirugo, G., Ben Hamida, C., Panayides, K., Ionannou, R, Beckmann, J., Mandel, J. L., Hentafi, F., Koenig, M., and Middleton, L., 1993, Friedrich’s ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families, Neurology 43:2179–2183.PubMedCrossRefGoogle Scholar
- Dexter, D. T., Brooks, D. J., Harding, A. E., Burn, D. J., Muller, D. P. R., Goss-Sampson, M. A., Jenner, P. G., and Marsden, C. D., 1994, Nigrostriatal function in vitamin E deficiency: clinical, experimental, and positron emission tomographic studies, Ann. Neurol. 35:298–303.PubMedCrossRefGoogle Scholar
- Einarson, L., and Telford, I. R., 1960, Effect of vitamin E deficiency on the central nervous system in various laboratory animals, Danske Videnskabernes Selskab 11:1–81.Google Scholar
- Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. F, and Butterfield, D. A., 1994, A model for beta amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer’s disease, Proc. Natl. Acad. Sci. USA 91:3270–3274.PubMedCrossRefGoogle Scholar
- Kayden, H. J., and Traber, M. G., 1986, Clinical, nutritional and biochemical consequences of apolipoprotein B deficiency, Adv. Exp. Biol. Med. 201:67–81.Google Scholar
- Nelson, J. S., 1980, Pathology of vitamin E deficiency, in: Vitamin E: A Comprehensive Treatise (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 391–428.Google Scholar
- Shriqui, C. L., Bradwejn, J., Annable, L., and Jones, B. D., 1992, Vitamin E in the treatment of tardive dyskinesia: a double-blind placebo-controlled study, Am. J. Psychiatry 140:391–393.Google Scholar
- Traber, M. G., Sokol, R. J., Burton, G. W., Ingold, K. U., Papas, A. M., Huffaker, J. E., and Kayden, H. J., 1990, Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha tocopherol into lipoproteins secreted by the liver, J. Clin. Invest. 85:397–407.PubMedCrossRefGoogle Scholar
- Uenohara, H., Imaizumi, S., Suzuki, J., and Yashimoto, T., 1988, The protective effect of mannitol, vitamin E and glucocorticoid on ischaemic brain injury: evaluation by chemiluminescence, energy metabolism and water content, Neurosurg. Res. 10:73–80.Google Scholar
- Von Voigtlander, P. F., Burian, M. A., Althaus, J. S., and Williams, L. R., 1990, Effects of chronic haloperidol on vitamin E levels and monoamine metabolism in rats fed normal and vitamin E-deficient diets, Res. Comm. Chem. Path. Pharmacol. 68:343–352.Google Scholar