Experimental Approach to Akinesia
Since the development of levodopa therapy, the quality of daily life of patients with Parkinson’s disease (PD) has dramatically improved. However, after several years of levodopa therapy, in most cases, both the efficacy of the levodopa therapy and the level of the patients’ motoricity gradually decrease (Rinne, 1981; Narabayashi, 1993; Marsden and Fahn, 1981; Lieberman et al., 1972; Bonnet et al., 1987). Therefore, it is clinically relevant to investigate why the therapeutic effect of levodopa on akinesia is limited, and why the levodopa effect on akinesia differs from that on other symptoms such as rigidity and tremor. We have no satisfactory answers to these questions, since the exact pathophysiological mechanisms underlying parkinsonian symptoms have not been elucidated.
KeywordsLateral Hypothalamus Bilateral Lesion Spontaneous Movement Levodopa Therapy Medial Forebrain Bundle
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