Wistar Rats

Splitting High and Low Responders to Novelty is Necessary in Basal Ganglia Research
  • Alexander R. Cools
  • B. Ellenbroek
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Striatal dopamine is involved in the pathophysiology of neuromental diseases such as Parkinson’s disease and schizophrenia. There exists a large individual vulnerability to these diseases. It is unknown to what extent this individual variability is genetically determined. If so, the question arises to what extent this refers to the HARDWARE, namely the MAKE-UP of the brain and the body, and/or the SOFTWARE, namely the REACTIVITY of the brain and the body?


Tyrosine Hydroxylase Prepulse Inhibition High Responder Maternal Deprivation Adult Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Casolini, B., Kabbaj, M., Leprat, F., Piazza, P.V., Rouge-Pont, Angelucci, L., Simon, H., Le Moal, M. and Maccari, S., 1993, Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons. Brain Res. 622: 311–314.PubMedCrossRefGoogle Scholar
  2. Cools, A.R., 1988, Transformation of emotion into motion: role of mesolimbic noradrenaline and neostriatal dopamine, in: Neurobiological approaches to human disease (D. Hellhamer, I. Florin and H. Weiner, eds.) Hans Huber Publishers, Toronto, pp 15–28.Google Scholar
  3. Cools, A.R., 1991, Differential role of mineralocorticoid and glucocorticoid receptors in the genesis of dexamphetamine-induced sensitization of mesolimbic, α1 adrenergic receptors in the ventral striatum, Neuroscience 43: 419–428.PubMedCrossRefGoogle Scholar
  4. Cools, A.R., Brachten, R., Heeren, D., Willemen, A., and Ellenbroek, B., 1990, Search after neurobiological profile of individual-specific features of Wistar rats, Brain Res. Bull.,24: 49–69.PubMedCrossRefGoogle Scholar
  5. Cools, A.R., Dierx, J., Coenders, C., Heeren, D., Ried, S., Jenks, B. and Ellenbroek, B., 1993a, Apomorphinesusceptible and apomorphine-unsusceptible Wistar rats differ in novelty-induced changes in hippocampal dynorphin B expression and two-way active avoidance: a new key in the search for the role of the hippocampal-accumbens axis, Behav. Brain Res., 55: 213–221.PubMedCrossRefGoogle Scholar
  6. Cools, A.R., Rots, N., Ellenbroek, B. and De Kloet, E.R., 1993b, Bimodal shape of individual variation in behavior of Wistar rats, Neuropsychobiology 28: 100–105.PubMedCrossRefGoogle Scholar
  7. Cools, A.R., Ellenbroek, B., Heeren, D. and Lubbers, L., 1993c, Use of high and low responders to novelty in rat studies on the role of the ventral striatum in radial maze performance, Can. J. Physiol. Pharmacol., 71:335–342.PubMedCrossRefGoogle Scholar
  8. Cools, A.R., Rots, N. and De Kloet, E.R., 1994, Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats: a new tool in the search for the function of the striatum in switching behavioural strategies, in: The Basal Ganglia IV (G. Percheron et al., eds.), Plenum Press, New York, pp. 507–515.CrossRefGoogle Scholar
  9. Ellenbroek, B.A. and Cools, A.R., 1990, Animal models with construct validity for schizophrenia, Behav. Pharmacol., 1:469–490.Google Scholar
  10. Ellenbroek, B.A. and Cools, A.R., 1993, Apomorphine-susceptible and apomorphine-unsusceptible rats differ in the amphetamine induced sensitization of α-receptors in the nucleus accumbens, Soc.Neurosci. Abs., 19: 823.Google Scholar
  11. Ellenbroek, B.A., Geyer, M.A. and Cools, A.R., 1995, The behaviour of APO-SUS rats in animal models with construct validity for schizophrenia, Neurosci., 15:7604–7611.Google Scholar
  12. Ellenbroek, B.A. and Cools, A.R., 1996, Dopamine susceptibility and information processing, Behav. Pharmacol., in press.Google Scholar
  13. Ellison, G., 1994, Stimulation-induced psychosis, the dopamine theory of schizophrenia, and the habenula, Brain Res. Rev., 19: 223–239.Google Scholar
  14. Gingras, M. and Cools, A.R., 1994, Evidence that high and low responders to novelty show differences in behavioural responses to dexamphetamine and ethanol, Soc. Neurosci. Abstr., 20: 1031.Google Scholar
  15. Mulders, W., Meek, J., Hafmans, T. and Cools, A.R., 1995a, The hypothalamic paraventricularis nucleus in two types of Wistar rats with different stress responses. I. Morphometric comparison, Brain Res., 689: 47–60.PubMedCrossRefGoogle Scholar
  16. Mulders, W., Meek, J., Schmidt, E. Hafmans, T. and Cools, A.R., 1995b, The hypothalamic paraventricular nucleus in two types of Wistar rats with different stress responses. II. Differential Fos-expression, Brain Res., 689: 61–70.PubMedCrossRefGoogle Scholar
  17. Piazza, P.V., Deminière, J., Le Moal, M. and Simon, H., 1989, Factors that predict individual vulnerability to amphetamine self-administration, Science 245: 1511–1513.PubMedCrossRefGoogle Scholar
  18. Piazza, P.V., Maccari, S., Deminière, J., Le Moal, M., Mormède, P., and Simon, H., 1991, Corticosterone levels determine individual vulnerability to amphetamine self-administration, Proc. Natl. Acad. Sci. USA 88: 2088–2092.CrossRefGoogle Scholar
  19. Plotsky, P.M., Cunningham, E.T. jr. and Widmaier, E.P., 1989, Catecholaminergic modulation of corticotropinreleasing factor and adrenocorticotropin secretion, Endocr. Rev., 10:437–458.Google Scholar
  20. Roozendaal, B. and Cools, A.R., 1994, Influence of the noradrenergic state of the nucleus accumbens in basolateral amygdala mediated changes in neophobia of rats, Behav. Neuroscience 108:1107–1118.Google Scholar
  21. Rots, N.Y., 1995, Dopamine and stress: studies with genetically selected rat lines. Thesis, State University of Leiden, The Netherlands.Google Scholar
  22. Rots, N.Y., Cools, A.R., De Jong, J. and De Kloet, E.R., 1995, Corticosteroid feedback resistance in rats genetically selected for increased dopamine responsiveness, J. Endocrinol. 7: 153–161.Google Scholar
  23. Schuurman, T., 1981, Endocrine processes underlying victory and defeat in the male rat, Thesis, State University of Groningen, The Netherlands.Google Scholar
  24. Sutanto, W., De Kloet, E.R., De Bree, F. and Cools, A.R., 1989, Differential corticosteroid binding characteristics to the mineralocorticoid and glucocorticoid receptors in the brain of pharmacogenetically-selected apomorphine-susceptible and apomorphine-unsusceptible Wistar rats, Neurosci. Res. Comm., 5: 19–26.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Alexander R. Cools
    • 1
  • B. Ellenbroek
    • 1
  1. 1.Department of Psychoneuropharmacology, Nijmegen Institute of NeurosciencesUniversity of NijmegenNijmegenThe Netherlands

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