Abstract
Huntington’s disease is an autosomal dominant, inherited neurodegenerative disorder of the basal ganglia in the human brain which results in the selective degeneration of the GABAergic output neurons of the striatum projecting to the globus pallidus and substantia nigra (Kowall et al., 1987; Martin and Gusella, 1986). Previous studies have shown that the selective degeneration of the GABAergic striatopallidal and striatonigral neurons in Huntington’s disease is accompanied by a substantial increase in GABAA receptors in the globus pallidus and substantia nigra (Faull et al., 1993, 1995; Penney and Pan, 1986; Penney and Young, 1982).
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Nicholson, L.F.B., Faull, R.L.M. (1996). GABAa Receptor Subunit Subtypes in the Human Putamen and Globus Pallidus in Huntington’s Disease. In: Ohye, C., Kimura, M., McKenzie, J.S. (eds) The Basal Ganglia V. Advances in Behavioral Biology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0194-1_52
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