GABAa Receptor Subunit Subtypes in the Human Putamen and Globus Pallidus in Huntington’s Disease

An in Situ Hybridization Study
  • Louise F. B. Nicholson
  • Richard L. M. Faull
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Huntington’s disease is an autosomal dominant, inherited neurodegenerative disorder of the basal ganglia in the human brain which results in the selective degeneration of the GABAergic output neurons of the striatum projecting to the globus pallidus and substantia nigra (Kowall et al., 1987; Martin and Gusella, 1986). Previous studies have shown that the selective degeneration of the GABAergic striatopallidal and striatonigral neurons in Huntington’s disease is accompanied by a substantial increase in GABAA receptors in the globus pallidus and substantia nigra (Faull et al., 1993, 1995; Penney and Pan, 1986; Penney and Young, 1982).


Basal Ganglion GABAA Receptor Globus Pallidus Hybridization Histochemistry Receptor Subunit mRNAs 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Louise F. B. Nicholson
    • 1
  • Richard L. M. Faull
    • 1
  1. 1.Department of Anatomy, School of MedicineThe University of AucklandAucklandNew Zealand

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