It is becoming increasingly clear that the basal ganglia are involved not only in motor disorders but also in learning and memory. Striatal neurons show dynamic changes in response to reward-related motor learning (see Graybiel et al., 1994) and the caudoputamen in the rat seems to mediate a certain type of motor learning (McDonald and White, 1993). Striosomes/patches, a subregion of the striatum, seem to be critical for reward-related learning (White and Hiroi, 1995). The nucleus accumbens, a ventral extension of the caudate-putamen (Heimer et al., 1985), regulates learning elicited by drug-induced reward (Nestler, 1992; Koob and Bloom, 1988; White and Hiroi, 1993).
KeywordsBasal Ganglion Striatal Neuron RNase Protection Assay Electroconvulsive Shock Supershift Assay
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