Chronic FRAs

Novel Transcription Factors Regulated in the Basal Ganglia by Chronic Neuronal Perturbations
  • N. Hiroi
  • J. S. Chen
  • H. E. Nye
  • E. J. Nestler
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


It is becoming increasingly clear that the basal ganglia are involved not only in motor disorders but also in learning and memory. Striatal neurons show dynamic changes in response to reward-related motor learning (see Graybiel et al., 1994) and the caudoputamen in the rat seems to mediate a certain type of motor learning (McDonald and White, 1993). Striosomes/patches, a subregion of the striatum, seem to be critical for reward-related learning (White and Hiroi, 1995). The nucleus accumbens, a ventral extension of the caudate-putamen (Heimer et al., 1985), regulates learning elicited by drug-induced reward (Nestler, 1992; Koob and Bloom, 1988; White and Hiroi, 1993).


Basal Ganglion Striatal Neuron RNase Protection Assay Electroconvulsive Shock Supershift Assay 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • N. Hiroi
    • 1
  • J. S. Chen
    • 1
  • H. E. Nye
    • 1
  • E. J. Nestler
    • 1
  1. 1.Department of Psychiatry, Division of Molecular PsychiatryYale University School of MedicineNew HavenUSA

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