Modulation of Glutamate-Induced Excitation of Striatal Neurons by Dopamine Iontophoresis in Awake, Unrestrained Rats

  • George V. Rebec
  • R. Christopher Pierce
  • Eugene A. Kiyatkin
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


The striatum receives cortical information via glutamatergic connections and processes it for output to nigral or pallidal neurons (Parent and Hazrati, 1995). Dopamine, which is released from thinly myelinated fibers that collateralize extensively throughout the striatum, appears to play a critical role in this processing function (Dunnett and Robbins, 1992; Groves, 1983). At the behavioral level, the interaction of these striatal transmitters has been implicated in the cognitive, emotional, motivational, and sensorimotor aspects of goal-directed movement (Carlsson and Carlsson, 1990; Groves, 1983).


Striatal Neuron Iontophoretic Application Pallidal Neuron General Motor Activation Glutamate Response 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • George V. Rebec
    • 1
  • R. Christopher Pierce
    • 1
  • Eugene A. Kiyatkin
    • 1
  1. 1.Program in Neural Science, Department of PsychologyIndiana UniversityBloomingtonUSA

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