Modulation of Glutamate-Induced Excitation of Striatal Neurons by Dopamine Iontophoresis in Awake, Unrestrained Rats
The striatum receives cortical information via glutamatergic connections and processes it for output to nigral or pallidal neurons (Parent and Hazrati, 1995). Dopamine, which is released from thinly myelinated fibers that collateralize extensively throughout the striatum, appears to play a critical role in this processing function (Dunnett and Robbins, 1992; Groves, 1983). At the behavioral level, the interaction of these striatal transmitters has been implicated in the cognitive, emotional, motivational, and sensorimotor aspects of goal-directed movement (Carlsson and Carlsson, 1990; Groves, 1983).
KeywordsStriatal Neuron Iontophoretic Application Pallidal Neuron General Motor Activation Glutamate Response
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