Summary
Apoptosis is a morphologically distinct process of cell death. Recently, non-physiologic agents, such as radiation, toxic substances and drugs, have been found to induce apoptosis. In this study, we report the presence of apoptotic cell death in cultured mesencephalic neurons treated with MPP+ and in the monkey substantia nigra after putaminal injection of MPTP by the TdT-mediated dUTP-biotin nick-end labeling (TUNEL) method. Apoptosis may be an important mechanism of cell death in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) - induced parkinsonism.
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Mochizuki, H., Goto, K., Imai, H., Mizuno, Y. (1996). Apoptosis in MPP+-Treated Mesencephalic-Striatal Co-Culture and MPTP-Induced Hemiparkinsonian Monkeys. In: Ohye, C., Kimura, M., McKenzie, J.S. (eds) The Basal Ganglia V. Advances in Behavioral Biology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0194-1_44
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DOI: https://doi.org/10.1007/978-1-4899-0194-1_44
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