Apoptosis in MPP+-Treated Mesencephalic-Striatal Co-Culture and MPTP-Induced Hemiparkinsonian Monkeys

  • Hideki Mochizuki
  • Keigo Goto
  • Hisamasa Imai
  • Yoshikuni Mizuno
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Apoptosis is a morphologically distinct process of cell death. Recently, non-physiologic agents, such as radiation, toxic substances and drugs, have been found to induce apoptosis. In this study, we report the presence of apoptotic cell death in cultured mesencephalic neurons treated with MPP+ and in the monkey substantia nigra after putaminal injection of MPTP by the TdT-mediated dUTP-biotin nick-end labeling (TUNEL) method. Apoptosis may be an important mechanism of cell death in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) - induced parkinsonism.


Amyotrophic Lateral Sclerosis Tyrosine Hydroxylase TUNEL Method Ventral Mesencephalon Positive Nuclear Staining 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Hideki Mochizuki
    • 1
  • Keigo Goto
    • 1
  • Hisamasa Imai
    • 1
  • Yoshikuni Mizuno
    • 1
  1. 1.Department of NeurologyJuntendo University School of MedicineBunkyo-ku, Tokyo 113Japan

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