Abstract
The activity of 513 units in external and internal segments of the human Globus Pallidus (GPe, GPi) analyzed during 24 stereotactic operations in parkinsonian patients made it possible to clarify the characteristics of the evoked activity of pallidal units during the performance of a verbally cueing motor tasks and to reveal the role of GP in the organization of voluntary movement in man.
Microelectrode recordings as the physiological identification of some thalamic nuclei and pallidum required during stereotactic operations for the treatment of parkinsonism (Lenz et al., 1990; Tasker et al., 1987; Raeva, 1986, 1972; Ohye, 1982; Jasper and Bertrand, 1966; Albe-Fessard et al., 1962) provide a unique opportunity to investigate how information for a verbally cueing voluntary movement is processed in human single neurons (Raeva, 1986, 1978, 1977, 1972). The aim of the present study was to analyze the characteristics of evoked activity (EA) patterns of pallidal units during the performance of a goal-directed movement in response to verbal commands and to reveal the role of the Globus Pallidus (GP) in processing of the motor information in awake human brain.
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Albe-Fessard, D., Arfel, G., Guiot, G., Hardy, J., Vourch, G., Hertzog, E., Aleonard, P., and Derome, P., 1962, Dérivations d’activités spontanées et evoquées dans les structures cérébrales profondes de l’homme, Rev.Neurol. 106: 89–105.
Alexander, G.E., DeLong, M.R., and Strick, P.L., 1986, Parallel organization of functionally segregated circuits linking basal ganglia and cortex, Ann.Rev.Neurosci. 9:357–384.
DeLong, M.R., Crutcher, M.D., and Georgopoulos. A.P., 1985, Primate globus pallidus and subthalamic nucleus: functional organization, J.Neurophys. 53: 530–543.
Graybiel, A.M., Aosaki, J., Flaherty, A.W., and Kimura, M., 1994, The basal ganglia adaptive motor control, Science 265: 1826–1831.
Jasper, H.H., and Bertrand, G., 1966, Thalamic units involved in somatic sensation and voluntary movement in man., in: The Thalamus, (D.P. Purpura, and M.D. Yahr, eds.), Columbia University Press, New York, pp.365–390.
Ilinsky, I., Tourtellotte, W.G., and Kultas-Ilinsky, K., 1993, Anatomical Distinction between the two basal ganglia afferent territories in the primate motor thalamus, Stereotact.Funct.Neurosurg. 60: 62–69.
Lenz, F.A., Kwan, H.C., Dostrovsky, J.O., Tasker, R.R., Murphy, J.T., and Lenz, Y.E., 1990, Single unit analysis of the human ventral thalamic nuclear group. Activity correlated with movement, Brain 113(6): 1795–1821.
Nambu, A., Yoshida, S., Tambuchi, I., and Jinnai, K., 1993, Movement-related activity in the pallido-thalamocortical loop, Biomed. Res. 14, Suppl. 1, pp.31–35.
Ohye, C., 1982, Depth microelectrode studies. In: Stereotaxy of the human brain. Anatomical, Physiological and clinical applications, (G. Schaltenbrand, and A.E. Walker, eds.), Georg Thieme Verlag, Stuttgart and New York, pp.372–389.
Percheron, G., Yelnik, J., and Francois, C., 1984, A golgi analysis of the primate globus pallidus. III. Spatial organization of the striopallidal complex, J.Comp.Neurol. 227: 214–227.
Raeva, S., 1972, Unit activity of some deep nuclear structures of the human brain during voluntary movements. in: Neurophysiology studied in man, (G. Somjen, ed.), Excerpta Medica, Amsterdam, pp. 64–78.
Raeva, S., 1977, Microelectrode investigations of unit activity of the human brain, (in russian). Nauka, Moscow, p. 208.
Raeva, S., 1978, Role of neurons of the neostriatum and nonspecific thalamus in the organization of goal-directed activity, Human Physiology, Plenum Publishing Corporation, New York, 3(6): 769–780.
Raeva, S., 1986, Localization in human thalamus of units triggered during “verbal commands,” voluntary movements and tremor, EEG and Clin.Neurophysiol. 63: 160–173.
Raeva, S., and Lukashev, A., 1993, Unit activity in human thalamic reticularis neurons. II. Activity evoked by significant and non-significant verbal or sensory stimuli. EEG and Clin.Neurophysiol. 86: 110–122.
Tasker, R.R., Lenz, F.A., Dostrovsky, G.O., Yamashiro, K., Chodakiewitz, G., and Albe-Fessard, D., 1987, The physiological basis of Vim thalamotomy for involuntary movement disorders, in: Clinical aspects of sensory and motor integration, (A. Struppler, and A. Weindle, eds.), Springer-Verlag, Berlin, Heidelberg, pp. 265–276.
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Raeva, S.N. (1996). Single Unit Activity of the Human Globus Pallidus during Verbally Cueing Voluntary Movement. In: Ohye, C., Kimura, M., McKenzie, J.S. (eds) The Basal Ganglia V. Advances in Behavioral Biology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0194-1_34
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