Neuronal Activity of Monkey Pedunculopontine Tegmental Nucleus Area II

Activity Related to Load Application on Working Arms
  • Katsushige Watanabe
  • Masaru Matsumura
  • Chihiro Ohye
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


A new posteroventral pallidotomy has been introduced for patients with Parkinson’s disease (Laitinen, 1992). By this pallidotomy, a muscle rigidity and akinesia can be effectively abolished. A gait disturbance and balance problems could also be improved. The effects of the new pallidotomy is assumed to be the results of the blockade of the increased inhibitory effect from internal segment of the globus pallidus on the motor thalamus, as well as on the brain stem target, that is the pedunculopontine tegmental nucleus (PPN)(Ohye, 1995).


Muscle Activity Firing Rate Muscle Tone Squirrel Monkey Heavy Load 
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  1. Brotchie, N., Iansek, R., and Home, M. K., 1991, Motor function of the monkey globus pallidus 1. Neuronal discharge and parameters of movement. Brain 114:1667–1683.Google Scholar
  2. Carpenter, M.B., Carleton, S.C., Keller, J.T., and Conte, P., 1981, Connections of the subthalamic nucleus in the monkey. Brain Res. 224:1–29.PubMedCrossRefGoogle Scholar
  3. Filion, M., 1979, Effects of interruption of the nigrostriatal pathway and of dopaminergic agents on the spontaneous activity of globus pallidus neurons in the awake monkey. Brain Res. 178:425–441.PubMedCrossRefGoogle Scholar
  4. Garcia-Rill, E., 1986, The Basal Ganglia and the Locomotor Regions. Brain Res. Rev. 11:47–63.CrossRefGoogle Scholar
  5. Garcia-Rill, E., 1991, The pedunculopontine nucleus. Prog. Neurobiol. 36:363–389.PubMedCrossRefGoogle Scholar
  6. Harnois, C., and Filion, M., 1982, Pallidofugal projections to thalamus and midbrain: a quantitative antidromic activation study in monkeys and cats. Exp. Brain Res. 47:277–285.PubMedCrossRefGoogle Scholar
  7. Hazrati, L.-N., and Parent, A., 1992, Projection of the deep cerebellar nuclei to the pedunculopontine nucleus in the squirrel monkey. Brain Res. 585:267–271.PubMedCrossRefGoogle Scholar
  8. Jackson, A., and Crossman, A.R., 1983, Nucleus tegmenti pedunculopontinus: Efferent connections with special reference to the basal ganglia, studied in the rat by anterograde and retrograde transport of horseradish peroxidase. Neuroscience. 10:725–765.PubMedCrossRefGoogle Scholar
  9. Kang, Y., and Kitai, S. T., 1990, Electrophysiological properties of pedunculopontine neurons and their postsynaptic response following stimulation of substantia nigra reticulata. Brain Res. 535:79–95.PubMedCrossRefGoogle Scholar
  10. Kelland, M. D., and Asdourian, D., 1989, Pedunculopontine tegmental nucleus-induced inhibition of muscle activity in the rat. Behav. Brain Res. 34:213–234.PubMedCrossRefGoogle Scholar
  11. Kimura, M, Aosaki, T., Hu, Y., Ishida, A., and Watanabe, K., 1992, Activity of primate putamen neurons is selective to the mode of voluntary movement: visually guided, self-initiated or memory-guided. Exp. Brain Res. 89:473–477.PubMedCrossRefGoogle Scholar
  12. Lai, Y. Y., and Siegel, J. M., 1990, Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation. J. Neurosci. 10:2727–2734.PubMedGoogle Scholar
  13. Laitinen, L. V., Bergenheim, A. T., and Hariz, M. I., 1992, Leksell’s posteroventral pallidotomy in the treatment of Parkinson’s disease. J. Neurosurg. 76:53–61.PubMedCrossRefGoogle Scholar
  14. Lavoie, B., and Parent, A., 1994a, Pedunculopontine nucleus in the squirrel monkey: Distribution of cholinergic and monoaminergic neurons in the mesopontine tegmentum with evidence for the presence of glutamate in cholinergic neurons. J.Comp.Neurol. 344:190–209.PubMedCrossRefGoogle Scholar
  15. Lavoie, B., and Parent, A., 1994b, Pedunculopontine nucleus in the squirrel monkey: Projections to the basal ganglia as revealed by anterograde tract-tracing methods. J.Comp.Neurol. 344:210–231.PubMedCrossRefGoogle Scholar
  16. Moon Edley, S., and Graybiel, A., 1983, The afferent and efferent connections of the feline nucleus tegmenti pedunculopontinus, pars compacta. J. Comp. Neurol. 217:187–215.CrossRefGoogle Scholar
  17. Mori, S., Shik, M. L., and Yagodnitsyn, A. S., 1977, Role of pontine tegmentum for locomotor control in mesencephalic cat. J. Neurophysiol. 40:284–295.PubMedGoogle Scholar
  18. Mori, S., Aoki, M., Kawahara, K., and Sakamoto, T., 1981, Level setting of postural tonus and initiation of locomotion by MLR stimulation. Adv. Physiol. Sci. 1:179–182.Google Scholar
  19. Mori, S., Kawahara, K., Aoki, M., and Tomiyama, T., 1982, Setting and resetting of level of postural muscle tone in decerebrate cat by stimulation of Brain Stem. J. Neurophysiol. 48:737–748.PubMedGoogle Scholar
  20. Olszewski, J., and Baxter, D., 1954, Cytoarchitecture of the human brain stem, New York: S. Karger.Google Scholar
  21. Ohye, C., 1995, Activity of the pallidal neurons related to voluntary and involuntary movements in humans. Role of basal ganglia in sensory motor association learning. Springer-Verlag Tokyo.: 190-200.Google Scholar
  22. Parent, A., and Hazrati, L.-N., 1993, Anatomical aspects of information processing in primates basal ganglia. Trends Neurosci. 16:111–116.PubMedCrossRefGoogle Scholar
  23. Parent, A., Mackey, A., and De Bellefeuille, L., 1983, The subcortical afferent to caudate nucleus and putamen in primate: A fluorescence retrograde double labeling study. Neuroscience. 10:1137–1150.PubMedCrossRefGoogle Scholar
  24. Rye, D. B., Saper, C. B., Lee, H. J., and Wainer, B. H., 1987, Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry and some extrapyramidal connections of the pontine tegmentum. J. Comp. Neurol. 259:315–528.CrossRefGoogle Scholar
  25. Suzuki, H., and Azuma, M., 1976, A glass-insulated “elgiloy” microelectrode for recording unit activity in chronic monkey experiments. Electroencephalogr. Clin. Neurophysiol. 41:93–95.PubMedCrossRefGoogle Scholar
  26. Webster, H.H., and Jones, B.E., 1988, Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II.Effect upon sleep-waking states. Brain Res. 458:285–302.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Katsushige Watanabe
    • 1
  • Masaru Matsumura
    • 1
  • Chihiro Ohye
    • 1
  1. 1.Department of NeurosurgeryGunma University School of MedicineMaebashi, Gunma, 371Japan

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