Neuronal Activity of Monkey Pedunculo-Pontine Tegmental Nucleus Area I
Anatomical studies have revealed dense connections between the pedunculopontine tegmental nucleus (PPN) and the basal ganglia (Figure 1). In primates, PPN receives massive afferents from the two output structures of the basal ganglia, that is, the substantia nigra pars reticulata and the internal pallidum. In turn, PPN projects profusely to the substantia nigra pars compacta and the subthalamic nucleus (Filion and Harnois, 1978; Harnois and Filion, 1980; Harnois and Filion, 1982; Parent and Hazrati, 1995). These ascending projections were found both ipsilaterally and contralaterally (Lavoie and Parent, 1994b). The existence of cerebello-tegmental projections, which are ipsilateral collaterals of the cerebello-thalamic projection, was also reported (Hazrati and Parent, 1992). Motor cortex (area 4) also sends fibers to PPN (Hartmann-Von Monakow et al., 1979; Moon Edley and Graybiel, 1983). PPN is a part of the mesencephalic locomotor region, from which locomotor movements are induced by its electrical stimulation (Garcia-Rill, 1986; Garcia-Rill, 1991).
KeywordsBasal Ganglion Squirrel Monkey Subthalamic Nucleus Pedunculopontine Nucleus Pedunculopontine Tegmental Nucleus
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