The Effects of Unilateral Nigrostriatal Dopamine Depletion on Learned Hand-Eye Coordination in Monkeys

  • Naoyuki Matsumoto
  • Toru Hanakawa
  • Shinichiro Maki
  • Minoru Kimura
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Dysfunction of the basal ganglia and the brain nuclei interconnected with them leads to disturbances of movement and cognition. The anatomical circuit arrangement within which the basal ganglia reside is unique. Their largest input station, the striatum, collects inputs from the entire neocortex and sends processed information through other parts of the areas of frontal cortex that have been implicated in motor planning and execution. These striatal circuits are modulated by the dopamine-containing nigrostriatal tract, which degenerates in Parkinson’s disease. The striatum also receives inputs from non-specific nuclei in the thalamus and from the amygdala. This arrangement and the multiple internal loops of the basal ganglia, have led to speculation that the basal ganglia are not simply related to motor execution per se. Instead, they may participate in motor planning including predictive control and motor sequencing, motor learning, and action repertories involving motivational and cognitive drive (Graybiel et al., 1994; Kimura, 1995).


Basal Ganglion Dopamine Neuron Dopamine Depletion Nigrostriatal Dopamine Saccade Onset 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Naoyuki Matsumoto
    • 1
  • Toru Hanakawa
    • 1
  • Shinichiro Maki
    • 1
  • Minoru Kimura
    • 1
  1. 1.Division of Higher Brain Function, Faculty of Health and Sport SciencesOsaka UniversityToyonaka, Osaka 560Japan

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