Cannabinoid Receptor-Mediated Modulation of Gabaergic Transmission in the Basal Ganglia

Implications for the Treatment of Parkinson’s Disease?
  • Y. P. Maneuf
  • J. M. Brotchie
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Cannabinoids have been known to humanity for thousands of years and have benn used for religious, pharmaceutical and recreational purposes. However, it is only since 1964, when Goani and Mechoulam isolated the most psychoactive compound of cannabis sativa, Δ9-tetrahydrocannabinol, that the scientific interest for these compounds started to develop. In the early nineties, the cloning and pharmacological characterization of the brain cannabinoid receptor (CB1) by Matsuda et al. (1990) allowed researchers to begin to comprehensively investigate the physiological importance of cannabinoid receptor-mediated actions.


Basal Ganglion Globus Pallidus Gaba Release GABAergic Transmission Gaba Uptake 
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  1. Albin, R.L., A.B. Young and Penney J.B., 1989, The functional anatomy of basal ganglia disorders, Trends Neurosc. 12: 366.CrossRefGoogle Scholar
  2. Anderson, L.A., J.J. Anderson, T.N. Chase and Walters, J.R., 1995, The cannabinoid agonists WIN 55,212-2 and CP 55, 940 attenuate rotational behavior induced by a dopamine D1 but not a D2 agonist in rat with unilateral lesions of the nigrostriatal pathway, Brain Res. 691: 106.PubMedCrossRefGoogle Scholar
  3. Banerjee, S.P, Snyder, S.H. and Mechoulam, R., 1975, Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes, J. Pharmacol. Exp. Ther. 194: 74.PubMedGoogle Scholar
  4. Bidaut-Russel, M., Devane, W.A. and Howlett, A.C., 1990, Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain, J.Neurochem. 55: 21.CrossRefGoogle Scholar
  5. Childers, S.R., Sexton, T. and Roy, M.B., 1994, Effects of anandamide on cannabinoid receptors in rat brain membranes, Biochem. Pharmacol. 47: 711.PubMedCrossRefGoogle Scholar
  6. Gaoni, Y., and Mechoulam, R., 1964, Isolation, structure and partialsynthesis of anactive constituent of hashish, J. Am. Chem.Google Scholar
  7. Glass, M., Faull, R.L.M and M. Dragunow, M., 1993, Loss of cannabinoid receptors in the substantia nigra in Huntington’s disease, Neuroscience 56: 523.PubMedCrossRefGoogle Scholar
  8. Guastella, J., Nelson, N., Nelson, H., Czyzyk, L., Keinan, S., Miedel, M.C., Davidson, N., Lester, H.A. and B.I. Kanner, 1990, Cloning and expression of a rat brain GABA transporter, Science 249, 1303.PubMedCrossRefGoogle Scholar
  9. Herkenham, M., Lynn, A.B., Little, M.D., Johnson, M.R., Melvin, L.S., de Costa, B.R. and Rice, K.C., 1990, Cannabinoid receptor localization in brain., Proc. Natl. Acad. Sci. U.S.A. 87: 1932.PubMedCrossRefGoogle Scholar
  10. Herkenham, M., Lynn, A.B., de Costa, B.R. and Richfield, E.K., 1991, Neuronal localization of cannabinoid receptors in the basal ganglia of the rat, Brain Res. 547: 267.PubMedCrossRefGoogle Scholar
  11. Iversen, L.L. and Neal, M.J., 1968, The uptake of [3H]-GABA by slices of rat cerebral cortex, J. Neurochem. 15: 1141.PubMedCrossRefGoogle Scholar
  12. Kirby, M.T., Hampson, R.E. and Deadwyler, S.A., 1994, Pre-and post-synaptic effects of the cannabinoid receptor agonist WIN 55, 212-2 on synaptic potential in the dentate gyms. Soci. Neurosci. Abstr. 305.11.Google Scholar
  13. Maneuf, Y.P., Mitchell I.J., Crossman A.R. and Brotchie, J.M., 1994, On the role of enkephalin-GABA transmission in the GABAergic striatal efferents to the globus pallidus, Exp. Neurol. 125: 65.PubMedCrossRefGoogle Scholar
  14. Maneuf, Y.P., Crossman A.R. and J.M. Brotchie, in press, Modulation of GABAergic transmission in the globus pallidus by the synthetic cannabinoid WIN 55, 212-2, Synapse.Google Scholar
  15. Martin, J.B. and Gusella, J.F., 1986, Huntington’s disease: Pathogenesis and management. New Eng. J. Med. 315: 1267.PubMedCrossRefGoogle Scholar
  16. Matsuda, L.A., Bonner, T.I. and Lolait, S.J., 1993, Localization of cannabinoid receptor mRNA in the rat brain, J. Comp. Neurol. 327: 535.PubMedCrossRefGoogle Scholar
  17. Pertwee, R.G., 1988, Psychotropic cannabinoids, Pharmacol. Ther. 36: 189.PubMedCrossRefGoogle Scholar
  18. Pertwee, R.G. and Wickens, A.P., 1991, Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoids, Neuropharmacology 30: 237.PubMedCrossRefGoogle Scholar
  19. Pertwee, R.G., 1994, The evidence for the existence of cannabinoid receptors, Gen. Pharmacol. 24: 811.Google Scholar
  20. Reichman, M., Nen, W. and Hokin, L.E., 1988, Δ9-tetrahydrocannabinol increases arachidonic acid levels in guinea pig cerebral cortex slices, Mol. Pharmacol. 34: 823.PubMedGoogle Scholar
  21. Rinaldi-Carmona, M., Barth, F., Heaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., Ferrera. P., Soubrie, P., Breliere, J.C. and Le Fur, G., 1994, SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor, FEBS lett. 350: 240.PubMedCrossRefGoogle Scholar
  22. Scheel-Kruger, J., Magelund, G. and Olianas, M.C., 1981, Role of GABA in the striatal output system: globus pallidus, nucleus entopeduncularis, substantia nigra and nucleus subthalamicus, in: GABA and the basal ganglia, (G. Di Chiara and G.L. Gessa, eds. Raven Press, New York) p. 165.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Y. P. Maneuf
    • 1
  • J. M. Brotchie
    • 1
  1. 1.Division of Neuroscience, School of Biological SciencesUniversity of ManchesterManchesterUK

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