The Role of Adenosine A2a Receptors in Regulating Gabaergic Synaptic Transmission in Striatal Medium Spiny Neurons
There is growing evidence that adenosine is a potent inhibitor of neuronal activity in the central (CNS) and peripheral nervous systems. Four major subtypes of adenosine receptors, A1 A2a, A2b, and A3, have been characterized (see review by Abbracchio et al., 1993). Among them, only A1 receptors have been known to serve to modulate synaptic transmission in the mammalian CNS. In contrast to the widespread distribution of the A1 and A2b receptor in brain, A2a receptors appear to be confined to the striatum, nucleus accumbens and olfactory tubercle (Jarvis and Williams, 1989; Parkinson and Fredholm, 1990; Martinez-Mir et al., 1991).
KeywordsMedium Spiny Neuron Striatal Medium Spiny Neuron Receptor Selective Agonist GABAergic Synaptic Transmission IPSC Amplitude
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