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Effects of HIV-1 and HIV-1 Envelope Glycoproteins on Signaling Pathways in Human T Lymphocytes

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Immunology of HIV Infection

Abstract

HIV-1 infection is unique with regard to immune responses, in which there is evidence for immune paradox, i. e., both immune activation and immune suppression. Immune stimulation is evident by elevated levels of various cytokines and hyperimmunoglobulinemia, whereas immune suppression is associated with quantitative and qualitative deficiency of T cells, especially of CD4+ T cells (reviewed in Fauci, 1988). It appears that HIV-1 or its envelope glycoproteins (gp160, gp120) can induce these paradoxical changes by various mechanisms, including blocking CD4-major histocompatibility complex (MHC) class II interaction and by altering signal transduction pathway. In this chapter, I will review the role of HIV-1 and its glycoproteins in activation and downregulation of signaling pathways in human T cells.

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Authors and Affiliations

  1. Division of Basic and Clinical Immunology, University of California, Irvine, California, 92697, USA

    Sudhir Gupta

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  1. Sudhir Gupta
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  1. University of California, Irvine, California, USA

    Sudhir Gupta M.D., Ph.D.

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© 1996 Springer Science+Business Media New York

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Gupta, S. (1996). Effects of HIV-1 and HIV-1 Envelope Glycoproteins on Signaling Pathways in Human T Lymphocytes. In: Gupta, S. (eds) Immunology of HIV Infection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0191-0_6

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  • DOI: https://doi.org/10.1007/978-1-4899-0191-0_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0193-4

  • Online ISBN: 978-1-4899-0191-0

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