HIV in Lymph Node and Thymus

  • Dhavalkumar D. Patel
  • Laura P. Hale
  • Barton F. Haynes


CD4, the receptor for HIV-1 on host immune cells, is expressed at varying levels on a wide variety of immune cell types. Many of the stromal and lymphoid cell types of the thymus and lymph nodes express CD4 and are infected by HIV during the course of systemic HIV infection. However, a variety of cell types in lymph node and thymus are damaged in HIV infection either as a direct consequence of HIV infection, or as a consequence of being targeted for damage by anti-HIV immune responses.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Germinal Center Simian Immunodeficiency Virus 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Dhavalkumar D. Patel
    • 1
  • Laura P. Hale
    • 2
  • Barton F. Haynes
    • 1
  1. 1.Departments of Medicine and Immunology, and Center for AIDS ResearchDuke University Medical CenterDurhamUSA
  2. 2.Department of PathologyDuke University Medical CenterDurhamUSA

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