Growth Factors in the Treatment of HIV Disease

  • David T. Scadden
  • David W. Golde


Cytokines have been portrayed as both sinner and saint in HIV disease as they play a role in both the pathogenesis of disease progression as well as its treatment. The contribution of cytokine dysregulation to the evolution of clinical decline following HIV infection has been suspected as an explanation for escape from latency as well as the wasting syndrome in advanced disease. More recently, cytokines have been implicated pathogenically in associated conditions such as Kaposi’s sarcoma and non-Hodgkin’s lymphoma (Masood et al., 1995; Wang et al., 1995; Pluda et al., 1993). While some cytokines are believed to be involved in the disease process, others have attracted attention for possible positive therapeutic manipulation of the immune response. The use of interleukin (IL)-2, IL-12, and others with potential in this setting are reviewed elsewhere in this volume.


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Immune Thrombocytopenic Purpura Mycobacterium Avium Complex Recombinant Human Erythropoietin 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • David T. Scadden
    • 1
  • David W. Golde
    • 2
    • 3
  1. 1.Massachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Cornell University Medical CollegeNew YorkUSA

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