Immunopathogenesis of Kaposi’s Sarcoma

  • Felipe Samaniego
  • Robert C. Gallo


Kaposi’s sarcoma (KS) is a proliferative disease of vascular origin and is the most frequent tumor of human immunodeficiency virus type 1 (HIV-1)-infected individuals, particularly of homosexual and bisexual men (Friedman-Kien et al., 1981; Havercos et al., 1985; Safai et al., 1985). In patients with acquired immunodeficiency syndrome (AIDS), KS (AIDS-KS) generally has an aggressive and rapid course that is characterized by widely distributed skin lesions, and early dissemination to visceral organs (Safai et al., 1985; Gottlieb and Ackerman, 1982). Other clinical types of KS include classical KS, an indolent disease that affects the lower extremities of elderly men of Mediterranean origin. Iatrogenic KS occurs in 5% of recipients of solid organ transplants, especially those taking glucocorticoids for immune suppression. Endemic KS occurs primarily in men of sub-Saharan Africa origin (Taylor et al., 1972; Slavin et al., 1969).


Vascular Endothelial Growth Factor Human Immunodeficiency Virus Type Spindle Cell Normal Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Felipe Samaniego
    • 1
  • Robert C. Gallo
    • 1
  1. 1.Institute of Human Virology, Medical Biotechnology CenterUniversity of MarylandBaltimoreUSA

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