T-Cell Epitopes of HIV-1 Envelope Glycoprotein

  • Christopher B. Buck
  • Robert F. Siliciano


The presentation of viral proteins to T cells is a critical early step in the immune response to HIV-1. From the initial surge of cytotoxic T-lymphocyte (CTL) activity observed during the resolution of the acute viremia of early HIV-1 infection (Yasutomi et al., 1993b; Koup et al., 1994), to the T-helper-cell (Th)-driven production of HIV-1-specific antibodies, immune responses to HIV-1 are critically dependent on the activities of T cells. It is thus important to understand how HIV-1 proteins are processed for T-cell recognition, and which regions (or epitopes) of these proteins are recognized in T-cell responses to the virus. The delineation of the HIV-1 epitopes presented to T cells has opened new avenues for exploration of host defense against virus infection and for the design of potential vaccines and therapeutic strategies.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Synthetic Peptide Envelope Glycoprotein Transporter Associate With Antigen Presentation 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Christopher B. Buck
    • 1
  • Robert F. Siliciano
    • 1
  1. 1.Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA

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