Abstract
The integrin family of cell adhesion receptors consists of over 20 members, which mediate cell surface interactions with extracellular matrix or (in some cases) with other cells (Akiyama et al., 1990b; Albelda and Buck, 1990; Clark, 1990; Hemler, 1990; Hogg, 1991; Ruoslahti, 1991; Shattil and Brugge, 1991; Yamada, 1991; Damsky and Werb, 1992; Ginsberg et al., 1992; Hynes, 1992; Akiyama and Yamada, 1993; Gailit and Clark, 1993; Glukhova and Thiery, 1993; Gumbiner, 1993; Juliano and Haskill, 1993; Sastry and Horwitz, 1993; Sonnenberg, 1993; Tuckwell et al., 1993; Zetter, 1993; Springer, 1994). Each integrin is a heterodimer, consisting of one a and one β subunit in a noncovalent complex. As summarized in Fig. 1, only certain combinations of integrins are observed: major groupings include integrins of the β1 subfamily and integrins containing the αv subunit. Changes in either the α or the β subunit of integrin heterodimers alter their specificity for ligands, as summarized in Table I.
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Yamada, K.M., Gailit, J., Clark, R.A.F. (1988). Integrins in Wound Repair. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_9
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