Role of Platelet-Derived Growth Factor in Vivo

  • Carl-Henrik Heldin
  • Bengt Westermark


Platelet-derived growth factor (PDGF) was originally identified as a mitogen for fibroblasts, smooth muscle cells, and glial cells (Kohler and Lipton, 1974; Ross et al., 1974; Westermark and Wasteson, 1976). PDGF was subsequently purified from human platelets (Antoniades et al., 1979; Deuel et al., 1981; Heldin et al., 1979; Raines and Ross, 1982). More recent studies have shown that PDGF is synthesized by a number of cell types and also acts on many different cell types (for reviews on PDGF, see Heldin and Westermark, 1990; Raines et al., 1990).


Idiopathic Pulmonary Fibrosis Mesangial Cell Derive Growth Factor Signal Transduction Molecule Excisional Wound 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Carl-Henrik Heldin
    • 1
  • Bengt Westermark
    • 2
  1. 1.Ludwig Institute for Cancer ResearchBiomedical CenterUppsalaSweden
  2. 2.Department of PathologyUniversity HospitalUppsalaSweden

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